ArticleCrystal growth & design2022
Crystallization-Induced Deracemization: Experiments and Modeling.
Article in Crystal growth & design, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Control of axial stereochemistry for the enantioselective construction of a QUINAP library.Chemical science · 2026Article
- Deracemization by coupling electrochemically assisted racemization and asymmetric crystallization.Chemical communications (Cambridge, England) · 2025Article
- Spontaneous chiral symmetry breaking in a single crystal.Chemical science · 2025Article
- On Solute Recovery and Productivity in Chiral Resolution through Solid-State Deracemization by Temperature Cycling.Crystal growth & design · 2024Article
- Article
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Authors and funding
3 authors.
Funding
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Abstract
Inspired by deracemization via temperature cycles, which enables the collection of crystals of the desired enantiomer from an initially racemic mixture, we focus in this work on an alternative batch process, namely crystallization-induced deracemization. This process starts with a suspension of enantiomerically pure crystals, which undergoes a simple cooling crystallization, coupled with liquid-phase racemization. The experimental and model-based analysis of such a process, carried out here, revealed that: (i) deracemization via temperature cycles is a safe choice to operate with high enantiomeric purity, although its throughput is limited by the suspension density; (ii) if the distomer is less prone to nucleation, crystallization-induced deracemization is a simple process; however, its performance is strongly limited by the solubility; (iii) the purity achieved with crystallization-induced deracemization can be increased by utilizing large seed mass and by optimizing the cooling profile or catalyst concentration. Alternatively, the purity increases via partial dissolution of the seeds, which resembles the heating part of the deracemization process via temperature cycles.
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Registered trials
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