Evidence map›Paper›PMID 35140541›Full record

ArticleClinical medicine insights. Circulatory, respiratory and pulmonary medicine2022

COVID-19 with Rapid Progression to Hypoxemia Likely due to Imbalance between Ventilation and Blood Flow: A Case Report.

Nobuyuki Koriyama, Akihiro Moriuchi, Kensaku Higashi, Tetsuro Kataoka, Takuro Arimizu, Go Takaguchi, Hideki Matsuoka, Maki Otsuka

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine insights. Circulatory, respiratory and pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nobuyuki KoriyamaNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.ORCID https://orcid.org/0000-0002-4830-7154
Akihiro MoriuchiNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Kensaku HigashiNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Tetsuro KataokaNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Takuro ArimizuNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Go TakaguchiNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Hideki MatsuokaNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Maki OtsukaNational Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
National Hospital Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn COVID-19 pneumonia, cases of severe hypoxemia in the early stage and cases of sudden deterioration in respiratory status due to silent hypoxia leading to death, have been reported. CASE SUMMARY: A 70-year-old Japanese man with essential hypertension, dyslipidemia, chronic kidney disease and emphysema was hospitalized with the novel coronavirus disease. He had hypoxemia that was disproportionate to the severity of pneumonia indicated by computed tomography (CT), along with coagulation abnormalities. We speculated that there was a high possibility that he had developed ventilation and blood flow imbalance due to pulmonary intravascular coagulopathy (PIC) or hypoxic pulmonary vasoconstriction (HPV). In this case, early, short-term combination therapy with remdesivir, nafamostat mesylate and low-dose dexamethasone (Dex) was successful.

conclusionIn COVID-19 patients with multiple comorbidities who have hypoxemia and coagulation abnormalities that are disproportionate to the severity of pneumonia on CT, it is important to commence antiviral and anticoagulant therapy as soon as possible, followed by use of a low dose of Dex.

Indexed as

COVID-19dexamethasonehypoxic pulmonary vasoconstrictionnafamostat mesylatepulmonary intravascular coagulopathyremdesivir

Identifiers

PMID35140541
PMCPMC8819745
OpenAlexW4210333865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.