Evidence map›Paper›PMID 35140477›Full record

ArticleInfection and drug resistance2022

Preliminary Investigation of Iron Acquisition in Hypervirulent

You Lan, Mao Zhou, Xin Li, Xuan Liu, Jun Li, Wenen Liu

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Virulence · 2025
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  5. Modulation ofBiomedicines · 2023
    Article
  6. Review
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  8. Article
  9. Article
  10. Epidemiological Features ofInfection and drug resistance · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

You LanDepartment of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, Hunan, 410008, People's Republic of China.
Mao ZhouDepartment of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, Hunan, 410008, People's Republic of China.
Xin LiDepartment of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, Hunan, 410008, People's Republic of China.
Xuan LiuDepartment of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, Hunan, 410008, People's Republic of China.
Jun LiDepartment of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, Hunan, 410008, People's Republic of China.
Wenen LiuDepartment of Clinical Laboratory, Xiangya Hospital Central South University, Changsha, Hunan, 410008, People's Republic of China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of outer membrane vesicles (OMVs) and related proteins in iron acquisition of hypervirulent

methodsThe OMVs of HVKP and cKP under iron-deficient and iron-sufficient media were extracted and purified by ultracentrifugation. Transmission electron microscopy (TEM) was used to identify OMVs. The quantitative proteomics were performed based on mass spectrometry.

resultsFour OMVs samples secreted by HVKP and cKP under iron-deficient and iron-sufficient environment were isolated and collected (HVKP OMVs under iron-deficient environment (A1), HVKP OMVs under iron-sufficient environment (A2), cKP OMVs under iron-deficient environment (B1), cKP OMVs under iron-sufficient environment (B2)). The amount of OMVs released by HVKP in iron-deficient medium was significantly larger than that in iron-sufficient medium (

conclusionAbove all, the results of this study suggest a potential role for OMVs in iron acquisition of HVKP and provide evidence of potential connections between OMVs and strong iron-acquisition ability of HVKP during iron limitation.

Indexed as

hypervirulent Klebsiella pneumoniaeiron acquisitionproteomics

Identifiers

PMID35140477
PMCPMC8818767
OpenAlexW4210590175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.