Evidence map›Paper›PMID 35140397›Full record

ArticleNature2022

A discrete neuronal population coordinates brain-wide developmental activity.

Bryce T Bajar, Nguyen T Phi, Jesse Isaacman-Beck, Jun Reichl, Harpreet Randhawa, Orkun Akin

Abstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Network state transitions during cortical development.Nature reviews. Neuroscience · 2024
    Review
  12. Synaptic promiscuity in brain development.Current biology : CB · 2024
    Review
  13. Article
  14. Article
  15. Cortical activity emerges in region-specific patterns during early brain development.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Review
  17. Article
  18. Hacking brain development to test models of sensory coding.bioRxiv : the preprint server for biology · 2023
    Article
  19. Review
  20. Coordinating early activity.Nature reviews. Neuroscience · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bryce T BajarDepartment of Biological Chemistry, Medical Scientist Training Program, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA.
Nguyen T PhiMolecular, Cellular, and Integrative Physiology Interdepartmental Graduate Program, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2215-1884
Jesse Isaacman-BeckDepartment of Neurobiology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Jun ReichlDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA.
Harpreet RandhawaDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA.
Orkun AkinDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA. akin.orkun@gmail.com.ORCID http://orcid.org/0000-0003-1719-4887

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Patterned, Stimulus-Independent Neuronal Activity In the Developing Drosophila Visual System: Origin and Contribution to Synaptic MaturationR01NS123376 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AKIN, ORKUN · 2021 to 2025
$2.1M
Determining the function and mechanism of spontaneous network activity during synaptogenesis in the Drosophila visual systemF30EY029952 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BAJAR, BRYCE T · 2019 to 2022
$149k
NEI NIH HHS F30 EY029952NIGMS NIH HHS T32 GM008042NINDS NIH HHS R01 NS123376
6 · The paper itself

Abstract

In vertebrates, stimulus-independent activity accompanies neural circuit maturation throughout the developing brain

Indexed as

NeuronsSynapsesAnimalsBrainDrosophilaNeurogenesis

Identifiers

PMID35140397
PMCPMC9020639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.