ArticleNature2022
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 81 citations in OpenAlex.
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- Article
- Article
- High-depth whole genome sequencing of premalignant breast lesions reveals rearrangement hotspots and personalized management opportunities.Nature communications · 2026Article
- PARP1 regulates the genomic ribonucleotide processing activity of TOP1 to prevent the formation of toxic TOP1-DNA adducts and the associated mutations.bioRxiv : the preprint server for biology · 2026Article
- Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation.bioRxiv : the preprint server for biology · 2026Article
- Nucleotide salvage, genome instability, and potential therapeutic applications.Nucleic acids research · 2026Review
- Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer.Science advances · 2026Article
- Visualizing DNA repair factor recruitment at sites of transcription in single cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Identification and validation of SUMOylation-related key genes for osteoarthritis through integration of single-cell, bulk RNA sequencing and animal model experiments.Frontiers in medicine · 2026Article
- ctDNA-derived copy-number signatures associated with immune checkpoint inhibitor resistance beyond PD-L1 and TMB in advanced NSCLC.Frontiers in oncology · 2026Article
- Nuclear spin hyperpolarization of pyruvate enables longitudinal monitoring of treatment response in intestinal tumor organoids.Magnetic resonance in medicine · 2025Article
- Colorectal Cancer: Differential Gene Expression and In Vitro Response to 5-Fluorouracil, Novel Fluoropyrimidine F10, and Potential Synergy with Lupeol.International journal of molecular sciences · 2025Article
- Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis.Oncogene · 2025Article
- Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy.Science (New York, N.Y.) · 2025Article
- Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration.Molecular neurodegeneration · 2025Review
- Article
- Divergent somatic mutation patterns among human cerebellar neuron types.bioRxiv : the preprint server for biology · 2025Article
- Sex differences in transcription-associated mutagenesis in the human germline.bioRxiv : the preprint server for biology · 2025Article
- Mutagenic Impact and Evolutionary Influence of Chemoradiotherapy in Hematologic Malignancies.Blood cancer discovery · 2025Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
22 authors at 16 institutions in 3 countries.
Martin A M Reijns *Disease Mechanisms, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK. martin.reijns@ed.ac.uk.ORCID http://orcid.org/0000-0002-5048-2752
David A Parry *Disease Mechanisms, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0376-7736
Thomas C Williams *Disease Mechanisms, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3866-1344
Ferran NadeuInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0003-2910-9440
Rebecca L HindshawInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Diana O Rios SzwedDisease Mechanisms, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0893-6324
Michael D NicholsonCancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2813-8979
Paula CarrollDisease Mechanisms, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.
Shelagh BoyleGenome Regulation, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.
Romina RoyoBarcelona Supercomputing Center (BSC), Barcelona, Spain.
Alex J CornishThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-3966-3501
Hang XiangInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.
Kate RidoutDepartment of Oncology, University of Oxford, Oxford, UK.
Genomics England Research Consortium
Colorectal Cancer Domain UK 100,000 Genomes Project
Anna SchuhDepartment of Oncology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3938-8490
Konrad AdenInstitute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.
Claire PallesInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-9670-2263
Elias CampoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0001-9850-9793
Tatjana StankovicInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-3780-274X
Martin S TaylorBiomedical Genomics, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK. martin.taylor@ed.ac.uk.ORCID http://orcid.org/0000-0001-7656-330X
Andrew P JacksonDisease Mechanisms, MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK. andrew.jackson@ed.ac.uk.ORCID http://orcid.org/0000-0002-8739-2646
Genomics England · GBQueen Mary University of London · GBInstitute of Cancer Research · GBInstitute of Genetics and Cancer · GBCentre for Human Genetics · GBEdinburgh Cancer Research · GBUniversity of Leeds · GBUniversity of Oxford · GBUniversity Hospital Schleswig-Holstein · DEBarcelona Supercomputing Center · ESCentro de Investigación Biomédica en Red de Cáncer · ESHospital Clínic de Barcelona · ESInstitute for Research in Biomedicine · ESUniversitat de Barcelona · ESUniversity of Birmingham · GBUniversity of Manchester · GB
Funding
Cancer Research UK 19771Cancer Research UK 25514Cancer Research UK 27589Cancer Research UK 27963Cancer Research UK 28640Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_UU_00007/11Medical Research Council MC_UU_00007/5Medical Research Council MC_UU_00009/2Medical Research Council MR/K001744/1Wellcome TrustWellcome Trust 204802/Z/16/Z
Abstract
The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair
Indexed as
DNA Topoisomerases, Type IGerm CellsMutagenesisNeoplasmsAnimalsDNA RepairHumansMutationRibonucleotidesDNA Topoisomerases, Type IRibonucleotidesTOP1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.