Evidence map›Paper›PMID 35140348›Full record

ArticleCommunications biology2022

Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism.

Emmanuel Saridakis, Rishi Vishwakarma, Josephine Lai-Kee-Him, Kevin Martin, Isabelle Simon, Martin Cohen-Gonsaud, Franck Coste, Patrick Bron, Emmanuel Margeat, Marc Boudvillain

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Multi-omics analyses of evolvedSynthetic and systems biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Emmanuel Saridakis *Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", Ag. Paraskevi, 15310, Athens, Greece.
Rishi Vishwakarma *CBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, INSERM, Montpellier, France.
Josephine Lai-Kee-HimCBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, INSERM, Montpellier, France.
Kevin MartinCBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, INSERM, Montpellier, France.
Isabelle SimonED 549, Santé, Sciences Biologiques & Chimie du Vivant, Université d'Orléans, Orléans, France.
Martin Cohen-GonsaudCBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, INSERM, Montpellier, France.
Franck CosteCentre de Biophysique Moléculaire, CNRS UPR4301, rue Charles Sadron, affiliated with Université d'Orléans, 45071, Orléans, cedex 2, France.ORCID http://orcid.org/0000-0002-7409-0470
Patrick BronCBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, INSERM, Montpellier, France. patrick.bron@cbs.cnrs.fr.ORCID http://orcid.org/0000-0002-3354-9513
Emmanuel MargeatCBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, INSERM, Montpellier, France. margeat@cbs.cnrs.fr.ORCID http://orcid.org/0000-0001-6063-6420
Marc BoudvillainLe Studium Loire Valley Institute for Advanced Studies, Orléans, France. marc.boudvillain@cnrs.fr.ORCID http://orcid.org/0000-0002-6398-9122
Centre National de la Recherche Scientifique · FRUniversité d'Orléans · FRNational Centre of Scientific Research "Demokritos" · GR

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-15-CE11-0024-02
6 · The paper itself

Abstract

The bacterial Rho factor is a ring-shaped motor triggering genome-wide transcription termination and R-loop dissociation. Rho is essential in many species, including in Mycobacterium tuberculosis where rho gene inactivation leads to rapid death. Yet, the M. tuberculosis Rho [

Indexed as

Mycobacterium tuberculosisBridged Bicyclo Compounds, HeterocyclicCryoelectron MicroscopyRho FactorTranscription FactorsbicozamycinBridged Bicyclo Compounds, HeterocyclicRho FactorTranscription Factors

Identifiers

PMID35140348
PMCPMC8828861
OpenAlexW4210920087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.