ArticleScientific reports2022
Ultrasound does not activate but can inhibit in vivo mammalian nerves across a wide range of parameters.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Therapeutic Effects and Mechanistic Insights of Low-Intensity Focused Ultrasound in Peripheral Neuropathic Pain.Journal of pain research · 2026Article
- Low-Intensity ultrasound for controlled excitation and suppression in rat sciatic nerve.Scientific reports · 2025Article
- Effect of focused ultrasound neuromodulation of the superior mesenteric plexus on insulin sensitivity and post-operative hyperglycemia in a swine model of surgical stress.Bioelectronic medicine · 2025Article
- A Wearable Dual-Mode Probe for Image-Guided Closed-Loop Ultrasound Neuromodulation.IEEE transactions on biomedical circuits and systems · 2025Article
- Low intensity trans-spinal focused ultrasound reduces mechanical sensitivity and suppresses spinal microglia activation in rats with chronic constriction injury.Bioelectronic medicine · 2025Article
- Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans.eLife · 2024Article
- Assessment of focused ultrasound stimulation to induce peripheral nerve activity and potential damageFrontiers in neurology · 2024Article
- Model-based correction of rapid thermal confounds in fluorescence neuroimaging of targeted perturbation.Neurophotonics · 2024Article
- Effects of focused ultrasound in a "clean" mouse model of ultrasonic neuromodulation.iScience · 2023Article
- Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Article
- Rib detection using pitch-catch ultrasound and classification algorithms for a novel ultrasound therapy device.Bioelectronic medicine · 2023Article
- Peripheral focused ultrasound stimulation and its applications: From therapeutics to human-computer interaction.Frontiers in neuroscience · 2023Review
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound (US) has been shown to stimulate brain circuits, however, the ability to excite peripheral nerves with US remains controversial. To the best of our knowledge, there is still no in vivo neural recording study that has applied US stimulation to a nerve isolated from surrounding tissue to confirm direct activation effects. Here, we show that US cannot excite an isolated mammalian sciatic nerve in an in vivo preparation, even at high pressures (relative to levels recommended in the FDA guidance for diagnostic ultrasound) and for a wide range of parameters, including different pulse patterns and center frequencies. US can, however, reliably inhibit nerve activity whereby greater suppression is correlated with increases in nerve temperature. By prohibiting the nerve temperature from increasing during US application, we did not observe suppressive effects. Overall, these findings demonstrate that US can reliably inhibit nerve activity through a thermal mechanism that has potential for various health disorders, though future studies are needed to evaluate the long-term safety of therapeutic ultrasound applications.
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