Evidence map›Paper›PMID 35140226›Full record

ArticleNature communications2022

Versioning biological cells for trustworthy cell engineering.

Jonathan Tellechea-Luzardo, Leanne Hobbs, Elena Velázquez, Lenka Pelechova, Simon Woods, Víctor de Lorenzo, Natalio Krasnogor

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  5. Self-documenting plasmids.Trends in biotechnology · 2025
    Review
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  8. Journal of bacteriology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jonathan Tellechea-Luzardo *Interdisciplinary Computing and Complex Biosystems (ICOS) Research Group, Newcastle University, Newcastle Upon Tyne, NE4 5TG, UK.ORCID http://orcid.org/0000-0003-2198-4558
Leanne Hobbs *Interdisciplinary Computing and Complex Biosystems (ICOS) Research Group, Newcastle University, Newcastle Upon Tyne, NE4 5TG, UK.ORCID http://orcid.org/0000-0003-2835-4241
Elena VelázquezSystems and Synthetic Biology Department, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.ORCID http://orcid.org/0000-0001-6648-1634
Lenka PelechovaInterdisciplinary Computing and Complex Biosystems (ICOS) Research Group, Newcastle University, Newcastle Upon Tyne, NE4 5TG, UK.ORCID http://orcid.org/0000-0002-6380-6744
Simon WoodsPolicy Ethics and Life Sciences (PEALS), Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.
Víctor de LorenzoSystems and Synthetic Biology Department, Centro Nacional de Biotecnología (CNB-CSIC), 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-6041-2731
Natalio KrasnogorInterdisciplinary Computing and Complex Biosystems (ICOS) Research Group, Newcastle University, Newcastle Upon Tyne, NE4 5TG, UK. Natalio.Krasnogor@newcastle.ac.uk.ORCID http://orcid.org/0000-0002-2651-4320
Newcastle University · GBCentro Nacional de Biotecnología · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

"Full-stack" biotechnology platforms for cell line (re)programming are on the horizon, thanks mostly to (a) advances in gene synthesis and editing techniques as well as (b) the growing integration of life science research with informatics, the internet of things and automation. These emerging platforms will accelerate the production and consumption of biological products. Hence, traceability, transparency, and-ultimately-trustworthiness is required from cradle to grave for engineered cell lines and their engineering processes. Here we report a cloud-based version control system for biotechnology that (a) keeps track and organizes the digital data produced during cell engineering and (b) molecularly links that data to the associated living samples. Barcoding protocols, based on standard genetic engineering methods, to molecularly link to the cloud-based version control system six species, including gram-negative and gram-positive bacteria as well as eukaryote cells, are shown. We argue that version control for cell engineering marks a significant step toward more open, reproducible, easier to trace and share, and more trustworthy engineering biology.

Indexed as

Biological ProductsAnimalsAutomationBacteriaBiotechnologyCell EngineeringCell LineGenetic EngineeringHumansMetabolic EngineeringSynthetic BiologyBiological Products

Identifiers

PMID35140226
PMCPMC8828774
OpenAlexW4220852013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.