Evidence map›Paper›PMID 35139765›Full record

ArticleJournal of toxicology and environmental health. Part A2022

Effects of life-stage and passive tobacco smoke exposure on pulmonary innate immunity and influenza infection in mice.

Lei Wang, Maya Rajavel, Ching-Wen Wu, Chuanzhen Zhang, Morgan Poindexter, Ciara Fulgar, Tiffany Mar, Jasmine Singh, Jaspreet K Dhillon, Jingjing Zhang and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicology and environmental health. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Lei WangCenter for Health and the Environment, University of California, Davis, CA, USA.
Maya RajavelCenter for Health and the Environment, University of California, Davis, CA, USA.
Ching-Wen WuCenter for Health and the Environment, University of California, Davis, CA, USA.ORCID 0000-0003-4302-9295
Chuanzhen ZhangCenter for Health and the Environment, University of California, Davis, CA, USA.
Morgan PoindexterCenter for Health and the Environment, University of California, Davis, CA, USA.
Ciara FulgarCenter for Health and the Environment, University of California, Davis, CA, USA.
Tiffany MarCenter for Health and the Environment, University of California, Davis, CA, USA.
Jasmine SinghCenter for Health and the Environment, University of California, Davis, CA, USA.
Jaspreet K DhillonCenter for Health and the Environment, University of California, Davis, CA, USA.
Jingjing ZhangCenter for Health and the Environment, University of California, Davis, CA, USA.
Yinyu YuanCenter for Health and the Environment, University of California, Davis, CA, USA.
Radek AbarcaCenter for Health and the Environment, University of California, Davis, CA, USA.
Wei LiSchool of Control Science and Engineering, Shandong University, Jinan, China.
Kent E PinkertonCenter for Health and the Environment, University of California, Davis, CA, USA.ORCID 0000-0001-9047-0353
University of California, Davis · USShandong Provincial QianFoShan Hospital · CNShandong University · CNSichuan University · CN

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Western Center for Agricultural Health and SafetyU54OH007550 · OH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FATHALLAH, FADI A · 2011 to 2025
$27.5M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
NIEHS NIH HHS P30 ES023513NIH HHS P51 OD011107NIOSH CDC HHS U54 OH007550
6 · The paper itself

Abstract

Limited data are available on the effects of perinatal environmental tobacco smoke (ETS) exposure for early childhood influenza infection. The aim of the present study was to examine whether perinatal versus adult ETS exposure might provoke more severe systemic and pulmonary innate immune responses in mice inoculated with influenza A/Puerto Rico/8/34 virus (IAV) compared to phosphate-buffered saline (PBS). BALB/c mice were exposed to filtered air (FA) or ETS for 6 weeks during the perinatal or adult period of life. Immediately following the final exposure, mice were intranasally inoculated with IAV or PBS. Significant inflammatory effects were observed in bronchoalveolar lavage fluid of neonates inoculated with IAV (FA+IAV or ETS+IAV) compared to PBS (ETS+PBS or FA+PBS), and in the lung parenchyma of neonates administered ETS+IAV versus FA+IAV. Type I and III interferons were also elevated in the spleens of neonates, but not adults with ETS+IAV versus FA+IAV exposure. Both IAV-inoculated neonate groups exhibited significantly more CD4 T cells and increasing numbers of CD8 and CD25 T cells in lungs relative to their adult counterparts. Taken together, these results suggest perinatal ETS exposure induces an exaggerated innate immune response, which may overwhelm protective anti-inflammatory defenses against IAV, and enhances severity of infection at early life stages (e.g., in infants and young children).

Indexed as

Tobacco Smoke PollutionAnimalsFemaleImmunity, InnateLungMiceMice, Inbred BALB CMice, Inbred C57BLOrthomyxoviridaeOrthomyxoviridae InfectionsPregnancyTobacco Smoke PollutionEnvironmental tobacco smokeimmune responseinfluenza viruslung

Identifiers

PMID35139765
PMCPMC8976777
OpenAlexW4211191158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.