Evidence map›Paper›PMID 35139743›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Inhibition studies of bacterial α-carbonic anhydrases with phenols.

Simone Giovannuzzi, Chad S Hewitt, Alessio Nocentini, Clemente Capasso, Gabriele Costantino, Daniel P Flaherty, Claudiu T Supuran

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates.Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  7. Article
  8. Review
  9. Activation studies with amino acids and amines of a β-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  10. The gram-negative bacteriumJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  11. Inhibition studies of the protozoan α-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  12. Article
  13. May Sulfonamide Inhibitors of Carbonic Anhydrases fromInternational journal of molecular sciences · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Simone GiovannuzziNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Italy.
Chad S HewittDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA.
Alessio NocentiniNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Italy.ORCID 0000-0003-3342-702X
Clemente CapassoDepartment of Biology, Agriculture and Food Sciences, CNR, Institute of Biosciences and Bioresources, Napoli, Italy.ORCID 0000-0003-3314-2411
Gabriele CostantinoDepartment of Food and Drug, University of Parma, Parco Area delle Scienze, Parma, Italy.
Daniel P FlahertyDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-8305-0606
Claudiu T SupuranNeurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Italy.ORCID 0000-0003-4262-0323
University of Florence · ITInstitute of Biosciences and Bioresources · ITPurdue Pharma (Canada) · CAPurdue University West Lafayette · USUniversity of Parma · IT

Funding

Repurposing novel selective drugs for treatment and decolonization of vancomycin resistant enterococciR01AI148523 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Daniel Patrick Flaherty, Mohamed Seleem · 2019 to 2026
$4.2M
Development of novel anti-Neisseria gonorrhoeae therapeutic agentsR01AI153264 · NIAID · PURDUE UNIVERSITY · PI FLAHERTY, DANIEL PATRICK · 2022 to 2025
$3.1M
NIAID NIH HHS R01 AI148523NIAID NIH HHS R01 AI153264
6 · The paper itself

Abstract

The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesDose-Response Relationship, DrugHumansMolecular StructureNeisseria gonorrhoeaePhenolsStructure-Activity RelationshipVibrio choleraeCarbonic Anhydrase InhibitorsCarbonic AnhydrasesPhenolsantibacterialsCarbonic anhydraseNeisseria gonorrhoeaephenolVibrio cholerae

Identifiers

PMID35139743
PMCPMC8843131
OpenAlexW4211082021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.