Evidence map›Paper›PMID 35139664›Full record

ReviewHypertension (Dallas, Tex. : 1979)2022

Genetics of Primary Aldosteronism.

Ute I Scholl

Open access · bronzeAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 106 citations in OpenAlex.

  1. Tumor-specificJCEM case reports · 2026
    Article
  2. Article
  3. Review
  4. Channelopathy linkingJCEM case reports · 2026
    Article
  5. Hypertensive Disorders of Pregnancy and Primary Aldosteronism.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  6. Article
  7. Is It Time to Retire Aldosterone Suppression Testing?American journal of hypertension · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. The genetics of hypertension.Nature reviews. Nephrology · 2026
    Review
  15. Hypertensive Disorders of Pregnancy and Primary Aldosteronism.medRxiv : the preprint server for health sciences · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. The Story of Aldosterone Escape.Journal of the American Society of Nephrology : JASN · 2026
    Review
  20. Identification of a novelFrontiers in genetics · 2026
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ute I SchollBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Functional Genomics, Germany.ORCID 0000-0002-0309-8045
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary aldosteronism is considered the commonest cause of secondary hypertension. In affected individuals, aldosterone is produced in an at least partially autonomous fashion in adrenal lesions (adenomas, [micro]nodules or diffuse hyperplasia). Over the past decade, next-generation sequencing studies have led to the insight that primary aldosteronism is largely a genetic disorder. Sporadic cases are due to somatic mutations, mostly in ion channels and pumps, and rare cases of familial hyperaldosteronism are caused by germline mutations in an overlapping set of genes. More than 90% of aldosterone-producing adenomas carry somatic mutations in K

Indexed as

AdenomaAdrenal Cortex NeoplasmsAdrenocortical AdenomaHyperaldosteronismAldosteroneG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHumansMutationSodium-Potassium-Exchanging ATPaseSteroid 11-beta-HydroxylaseAldosteroneG Protein-Coupled Inwardly-Rectifying Potassium ChannelsKCNJ5 protein, humanSodium-Potassium-Exchanging ATPaseSteroid 11-beta-Hydroxylaseadenomaaldosteronehyperaldosteronismmutation

Identifiers

PMID35139664
PMCPMC8997684
OpenAlexW4211042286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.