Evidence map›Paper›PMID 35139373›Full record

Trial reportCell reports2022

Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial.

Carolyn M Boudreau, John S Burke, Kiel D Shuey, Caitlin Wolf, Joanne Katz, James Tielsch, Subarna Khatry, Steven C LeClerq, Janet A Englund, Helen Y Chu and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Carolyn M BoudreauRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Harvard University, Cambridge, MA, USA.
John S BurkeRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Kiel D ShueyDepartment of Medicine, University of Washington, Seattle, WA, USA.
Caitlin WolfDepartment of Medicine, University of Washington, Seattle, WA, USA.
Joanne KatzDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
James TielschDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Subarna KhatryNepal Nutrition Intervention Project, Sarlahi, Kathmandu, Nepal.
Steven C LeClerqDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Nepal Nutrition Intervention Project, Sarlahi, Kathmandu, Nepal.
Janet A EnglundDepartment of Pediatrics, Seattle Children's Research Institute and University of Washington, Seattle, WA, USA. Electronic address: janet.englund@seattlechildrens.org.
Helen Y ChuDepartment of Medicine, University of Washington, Seattle, WA, USA. Electronic address: helenchu@uw.edu.
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@mgh.harvard.edu.
University of Washington · USJohns Hopkins University · USRagon Institute of MGH, MIT and Harvard · USHarvard University · USMilken Institute · USSeattle Children's Hospital · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
MOLECULAR BASIS OF VIRAL INFECTIVITYT32AI007245 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Aaron Gregory Schmidt · 1985 to 2026
$11.3M
Demystifying the antiviral activity of the IgG3+ antibody responseR37AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALTER, GALIT · 2015 to 2022
$5.8M
NIAID NIH HHS P30 AI060354NIAID NIH HHS R37 AI080289NIAID NIH HHS T32 AI007245
6 · The paper itself

Abstract

Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited antibodies provide protection in some but not all infants is incompletely understood. We comprehensively profiled the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination. Influenza-specific antibody subclass levels, Fc ɣ receptor (FCGR) binding levels, and antibody-dependent innate immune functions were all profiled in the mothers during pregnancy and at birth, as well as in cord blood. Vaccination increased influenza-specific antibody levels, antibody binding to FCGR, and specific antibody-dependent innate immune functions in both maternal and cord blood, with FCGR binding most enhanced via vaccination. Influenza-specific FCGR binding levels were lower in cord blood of infants who subsequently developed influenza infection. Collectively these data suggest that in addition to increased antibody amounts, the selective transfer of FCGR-binding antibodies contributes to the protective immune response in infants against influenza.

Indexed as

VaccinationAntibodies, ViralFemaleHumansInfantInfant, NewbornInfluenza, HumanInfluenza VaccinesPlacebosPregnancyAntibodies, ViralInfluenza VaccinesPlacebosadaptive immunityantibodyFc effector functionFc receptorinfluenzainnate immunitymaternal vaccinationplacental transfervaccination

Identifiers

PMID35139373
PMCPMC9026287
OpenAlexW4210924700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.