ArticleNeuron2022
Hippocampal-amygdala memory circuits govern experience-dependent observational fear.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules.Nature communications · 2026Article
- Individual differences in prosocial learning are represented in the hippocampal dorsal CA1.Nature neuroscience · 2026Article
- Post stress sensory contact with a male mouse is associated with altered social behavior in a female vicarious social defeat stress model.Experimental animals · 2026Article
- Article
- GABA signaling in NG2 glia mediates empathy-like behavior under observational social defeat.Nature communications · 2026Article
- Divergent BLA engram circuits orchestrate social preference dynamics in bystander male mice with self-experienced stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Heterosynaptic Interactions between the Dorsal and Ventral Hippocampus in Individual Medium Spiny Neurons of the Nucleus Accumbens Ventromedial Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Bisphenol S and Neurological Health: An Integrated Overview of Neurotoxicity and Underlying Mechanisms.Molecular neurobiology · 2026Review
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- Empathy and prosocial behavior powered by orexin-driven theta oscillations.Science (New York, N.Y.) · 2026Article
- Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.Annals of neurology · 2026Review
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- Heightened empathic responses led by imbalanced cortico-amygdala circuit inbioRxiv : the preprint server for biology · 2025Article
- Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.Psychological medicine · 2025Article
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
Corrections and comments
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Authors and funding
7 authors.
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Abstract
The empathic ability to vicariously experience the other's fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior similar fear experience in the observer and social familiarity with the demonstrator. However, the neural circuit mechanisms of experience-dependent OF (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits in mice without involving the anterior cingulate cortex, considered a center of OF, mediate Exp OF. Dorsal HPC neurons generate fear memory engram cells in BLA encoding prior similar fear experiences, which are essential for Exp OF. On the other hand, ventral HPC neurons respond to the familiar demonstrator's aversive situation during Exp OF, which reactivates the fear memory engram cells in BLA to elicit Exp OF. Our study provides new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like Exp OF.
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