Evidence map›Paper›PMID 35139352›Full record

ArticleImmunity2022

Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.

Kelly M Cautivo, Peri R Matatia, Carlos O Lizama, Nicholas M Mroz, Madelene W Dahlgren, Xiaofei Yu, Julia Sbierski-Kind, Marcela T Taruselli, Jeremy F Brooks, Adam Wade-Vallance and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Influenza-induced tuft cell expansion alters ILC-mediated inflammation.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. IFNγ in human sepsis: a scoping review.Annals of intensive care · 2025
    Review
  18. The immunology of asthma.Nature immunology · 2025
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Kelly M CautivoDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Peri R MatatiaDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Carlos O LizamaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Nicholas M MrozDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Madelene W DahlgrenDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Xiaofei YuDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Julia Sbierski-KindDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Marcela T TaruselliDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jeremy F BrooksDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Adam Wade-VallanceBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Sofia E CaryotakisBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Anthony A ChangDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Hong-Erh LiangDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Julie ZikhermanDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Richard M LocksleyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Ari B MolofskyDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. Electronic address: ari.molofsky@ucsf.edu.
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Parasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8M
Localization and function of tissue type 2 lymphocytes during mixed inflammationR01AI162806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2022 to 2026
$2.8M
Defining group 2 innate lymphoid cell lung nichesR01HL142701 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2019 to 2022
$2.5M
Meningeal type 2 immunity in cortical synapse remodeling during brain development and injuryR01NS126765 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anna V Molofsky, Ari B Molofsky · 2022 to 2026
$2.3M
Regulation and function of allergic immune cells in visceral adipose tissueK08DK101604 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2014 to 2018
$811k
Defining group 2 innate lymphoid cell lung nichesR56HL142701 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2018 to 2018
$470k
NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL142701NHLBI NIH HHS R56 HL142701NIAID NIH HHS R01 AI026918NIAID NIH HHS R01 AI162806NIAID NIH HHS T32 AI007334NIDDK NIH HHS K08 DK101604NIDDK NIH HHS P30 DK063720NIGMS NIH HHS T32 GM136547NINDS NIH HHS R01 NS126765
6 · The paper itself

Abstract

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic repositioning during immune perturbations. Here, we used thick-section quantitative imaging to show that allergic inflammation drives invasion of lung and liver non-adventitial parenchyma by ILC2s and Th2 cells. However, during concurrent type 1 and type 2 mixed inflammation, IFNγ from broadly distributed type 1 lymphocytes directly blocked both ILC2 parenchymal trafficking and subsequent cell survival. ILC2 and Th2 cell confinement to adventitia limited mortality by the type 1 pathogen Listeria monocytogenes. Our results suggest that the topography of tissue lymphocyte subsets is tightly regulated to promote appropriately timed and balanced immunity.

Indexed as

AnimalsCell DeathCell MovementHypersensitivityImmunity, InnateInflammationInterferon-gammaInterleukin-33Interleukin-5Listeria monocytogenesListeriosisLiverLungLymphocyte SubsetsLysophospholipidsMiceIFNG protein, mouseInterferon-gammaInterleukin-33Interleukin-5LysophospholipidsSphingosinesphingosine 1-phosphate3D imagingallergic immunityILC2interferon gammalymphocyte nichesmixed inflammationTh2tissue immunologytype 2 immunity

Identifiers

PMID35139352
PMCPMC8852844
OpenAlexW4210870788

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.