Evidence map›Paper›PMID 35139333›Full record

ArticleExperimental eye research2022

Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.

John L Ubels, Cheng-Mao Lin, David A Antonetti, Monica Diaz-Coranguez, Cassandra R Diegel, Bart O Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Case Report: Expanding theFrontiers in pediatrics · 2026
    Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

John L UbelsDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA; Department of Biology, Calvin University, 3201 Burton St., SE, Grand Rapids, MI, 49546, USA. Electronic address: john.ubels@vai.org.
Cheng-Mao LinKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, 1000 Wall St, Ann Arbor, MI, 48105, USA.
David A AntonettiKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, 1000 Wall St, Ann Arbor, MI, 48105, USA.
Monica Diaz-CoranguezKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, 1000 Wall St, Ann Arbor, MI, 48105, USA.
Cassandra R DiegelDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
Bart O WilliamsDepartment of Cell Biology, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA. Electronic address: bart.williams@vai.org.
University of Michigan–Ann Arbor · USVan Andel Institute · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Unraveling the role of tPA in the neurovascular unitR01HL055374 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti, Daniel A Lawrence · 1995 to 2026
$8.6M
MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETESR01EY012021 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTONETTI, DAVID · 1998 to 2024
$8.6M
E75 IN THE DEVELOPING DROSOPHILA EYEF31EY007003 · NEI · YALE UNIVERSITY · PI SHILTON, ALYCIA N · 1999 to 2001
$14k
NEI NIH HHS F31 EY007003NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY012021NHLBI NIH HHS R01 HL055374NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Loss-of-function mutations in the Wnt co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), result in familial exudative vitreoretinopathy (FEVR), osteoporosis-pseudoglioma syndrome (OPPG), and Norrie disease. CRISPR/Cas9 gene editing was used to produce rat strains deficient in Lrp5. The purpose of this study was to validate this rat model for studies of hypovascular, exudative retinopathies. The retinal vasculature of wildtype and Lrp5 knockout rats was stained with Giffonia simplifolia isolectin B

Indexed as

Low Density Lipoprotein Receptor-Related Protein-5RetinaAnimalsClaudin-5Evans BlueFamilial Exudative VitreoretinopathiesMutationRatsStructure-Activity RelationshipClaudin-5Evans BlueLow Density Lipoprotein Receptor-Related Protein-5Lrp5 protein, ratBlood-retinal barrierClaudin-5CRISPR-Cas9FEVRFrizzled-4Lrp5NorrinRetinal vasculatureWnt signaling

Identifiers

PMID35139333
PMCPMC9295635
OpenAlexW4225707831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.