ArticlePlant physiology2022
The CCCH zinc finger protein C3H15 negatively regulates cell elongation by inhibiting brassinosteroid signaling.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Structural variation in the IAMH2 3' UTR underlies hypocotyl elongation during light adaptation in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2026Article
- MBNL1 hijacks a structured single-stranded distal DNA element to sustainScience advances · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Genome-Wide Identification and Characterization of C3H-ZFP Genes and Their Expression Under Salt and Cadmium Stress Conditions in Soybean.Current issues in molecular biology · 2026Article
- Identification of genetic loci and domestication gene GmZFP1 associated with soybean hypocotyl elongation in seedling stage by genome-wide association study.BMC plant biology · 2026Article
- Combined Analysis of BSA-Seq and RNA-Seq Reveals Candidate Genes forPlants (Basel, Switzerland) · 2025Article
- Genome-wide identification and expression analysis ofFrontiers in plant science · 2025Article
- Functional analysis ofFrontiers in plant science · 2025Article
- Interaction of the Transcription Factors BES1/BZR1 in Plant Growth and Stress Response.International journal of molecular sciences · 2024Review
- Ectopic expression ofForestry research · 2024Article
- Comparative Anatomical and Transcriptomics Reveal the Larger Cell Size as a Major Contributor to Larger Fruit Size in Apricot.International journal of molecular sciences · 2023Article
- Brassinosteroids affect wood development and properties ofFrontiers in plant science · 2023Article
- Hormone Regulation of CCCH Zinc Finger Proteins in Plants.International journal of molecular sciences · 2022Review
- Phosphorylation-mediated inactivation of C3H14 by MPK4 enhances bacterial-triggered immunity in Arabidopsis.Plant physiology · 2022Article
- Maize ZmBES1/BZR1-3 and -9 Transcription Factors Negatively Regulate Drought Tolerance in TransgenicInternational journal of molecular sciences · 2022Article
- The C3H gene PtZFP2-like in Pinellia ternata acts as a positive regulator of the resistance to soft rot caused by Pectobacterium carotovorum.Physiologia plantarumArticle
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11 authors at 4 institutions in 1 country.
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Abstract
Plant CCCH proteins participate in the control of multiple developmental and adaptive processes, but the regulatory mechanisms underlying these processes are not well known. In this study, we showed that the Arabidopsis (Arabidopsis thaliana) CCCH protein C3H15 negatively regulates cell elongation by inhibiting brassinosteroid (BR) signaling. Genetic and biochemical evidence showed that C3H15 functions downstream of the receptor BR INSENSITIVE 1 (BRI1) as a negative regulator in the BR pathway. C3H15 is phosphorylated by the GLYCOGEN SYNTHASE KINASE 3 -like kinase BR-INSENSITIVE 2 (BIN2) at Ser111 in the cytoplasm in the absence of BRs. Upon BR perception, C3H15 transcription is enhanced, and the phosphorylation of C3H15 by BIN2 is reduced. The dephosphorylated C3H15 protein accumulates in the nucleus, where C3H15 regulates transcription via G-rich elements (typically GGGAGA). C3H15 and BRASSINAZOLE RESISTANT 1 (BZR1)/BRI1-EMS-SUPPRESSOR 1 (BES1), two central transcriptional regulators of BR signaling, directly suppress each other and share a number of BR-responsive target genes. Moreover, C3H15 antagonizes BZR1 and BES1 to regulate the expression of their shared cell elongation-associated target gene, SMALL AUXIN-UP RNA 15 (SAUR15). This study demonstrates that C3H15-mediated BR signaling may be parallel to, or even attenuate, the dominant BZR1 and BES1 signaling pathways to control cell elongation. This finding expands our understanding of the regulatory mechanisms underlying BR-induced cell elongation in plants.
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