ArticleEuropean heart journal2022
Early and late-onset syncope: insight into mechanisms.
Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Head-up tilt testing in older syncope patients: a systematic review.Age and ageing · 2025Pooled it
- Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS) and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Guideline
- Syncope diagnostic evaluation in a southern European population: patterns of clinical practice and cost implications.BMC health services research · 2026Observational
- Diagnostic value of short-duration head-up tilt test for unexplained syncope: a non-inferiority study.BMC cardiovascular disorders · 2026Article
- Temperature- and humidity-modified associations between ambient air pollution and syncope outpatient visits: a time series analysis in Beijing, China.Scientific reports · 2026Article
- Prediction evaluation of the Tp-Te interval in patients with vasovagal syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Effects of cardioneuroablation for vasovagal syncope: ganglionated plexus localization by tentative anatomical ablation and high-frequency electrical stimulation.BMC cardiovascular disorders · 2025Article
- Clinical characteristics of psychogenic pseudosyncope in a population-based cohort.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Trends in syncope testing and admissions in the USA from 2006 through 2019.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Motor induced syncope after cerebral infarction: A case report and literature review.SAGE open medical case reports · 2025Article
- Carotid sinus massage in clinical practice: the Six-Step-Method.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- A Case of Complete Resolution of Repeated Syncope Attacks After a Right-Sided Carotid Endarterectomy.Cureus · 2024Article
- Adult vasovagal syncope with abdominal pain diagnosed by head-up tilt combined with transcranial doppler: a preliminary study.BMC neurology · 2024Article
- Cardioneuroablation for Cardioinhibitory Vasovagal Syncope: Rationale, Approaches, and Its Role in Long-Term Management.Current cardiovascular risk reports · 2024Article
- Syncope Secondary to Concomitant Ingestion of Tizanidine and Alcohol in a Patient With Alcohol Use Disorder.Cureus · 2024Article
- Gut microbiota composition is altered in postural orthostatic tachycardia syndrome and post-acute COVID-19 syndrome.Scientific reports · 2024Article
- Asystole on loop recorder in patients with unexplained syncope and negative tilt testing: age distribution and clinical predictors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Recent Advances and Future Directions in Syncope Management: A Comprehensive Narrative Review.Journal of clinical medicine · 2024Review
- Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age.Frontiers in cardiovascular medicine · 2024Article
- Observational
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsUnexplained syncope is an important clinical challenge. The influence of age at first syncope on the final syncope diagnosis is not well studied. METHODS AND
resultsConsecutive head-up tilt patients (n = 1928) evaluated for unexplained syncope were stratified into age groups <30, 30-59, and ≥60 years based on age at first syncope. Clinical characteristics and final syncope diagnosis were analysed in relation to age at first syncope and age at investigation. The age at first syncope had a bimodal distribution with peaks at 15 and 70 years. Prodromes (64 vs. 26%, P < 0.001) and vasovagal syncope (VVS, 59 vs. 19%, P < 0.001) were more common in early-onset (<30 years) compared with late-onset (≥60 years) syncope. Orthostatic hypotension (OH, 3 vs. 23%, P < 0.001), carotid sinus syndrome (CSS, 0.6 vs. 9%, P < 0.001), and complex syncope (>1 concurrent diagnosis; 14 vs. 26%, P < 0.001) were more common in late-onset syncope. In patients aged ≥60 years, 12% had early-onset and 70% had late-onset syncope; older age at first syncope was associated with higher odds of OH (+31% per 10-year increase, P < 0.001) and CSS (+26%, P = 0.004). Younger age at first syncope was associated with the presence of prodromes (+23%, P < 0.001) and the diagnoses of VVS (+22%, P < 0.001) and complex syncope (+9%, P = 0.018).
conclusionIn patients with unexplained syncope, first-ever syncope incidence has a bimodal lifetime pattern with peaks at 15 and 70 years. The majority of older patients present only recent syncope; OH and CSS are more common in this group. In patients with early-onset syncope, prodromes, VVS, and complex syncope are more common.
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