Evidence map›Paper›PMID 35138935›Full record

ArticleMolecular biology of the cell2022

Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in

Baixue Yao, Seth Donoughe, Jonathan Michaux, Edwin Munro

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Actin network heterogeneity tunes activator-inhibitor dynamics at the cell cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Substrate stress relaxation regulates neural stem cell fate commitment.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
  9. Article
  10. Article
  11. Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves.bioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Baixue YaoDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637.
Seth DonougheDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637.
Jonathan MichauxRobotics Institute, University of Michigan, Ann Arbor, MI 48109.
Edwin MunroDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637.
University of Chicago · USUniversity of Michigan · US

Funding

Dynamics and regulation of actomyosin contractility in the C. elegans embryoR01GM098441 · NIGMS · UNIVERSITY OF CHICAGO · PI MUNRO, EDWIN MARSHALL · 2011 to 2020
$2.9M
NIGMS NIH HHS R01 GM098441
6 · The paper itself

Abstract

Pulsatile RhoA dynamics underlie a wide range of cell and tissue behaviors. The circuits that produce these dynamics in different cells share common architectures based on fast positive and delayed negative feedback through F-actin, but they can produce very different spatiotemporal patterns of RhoA activity. However, the underlying causes of this variation remain poorly understood. Here we asked how this variation could arise through modulation of actin network dynamics downstream of active RhoA in early

Indexed as

ActinsCaenorhabditis elegansActomyosinAnimalsForminsrhoA GTP-Binding ProteinZygoteActinsActomyosinForminsrhoA GTP-Binding Protein

Identifiers

PMID35138935
PMCPMC9265151
OpenAlexW4210827906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.