ArticleHypertension (Dallas, Tex. : 1979)2022
Hypertension-Mediated Organ Damage: Prevalence, Correlates, and Prognosis in the Community.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Pooled it
- Machine Learning in Left Ventricular Hypertrophy Detection: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Pharmacotherapy for mild hypertension.The Cochrane database of systematic reviews · 2025Pooled it
- European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice.Nature reviews. Cardiology · 2025Guideline
- Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized Clinical Trial.JAMA neurology · 2026Trial
- Trial
- Prevalence of target organ damage in rural Kenya and The Gambia: a cross-sectional study.The Lancet regional health. Africa · 2026Article
- Efficacy and Cost-Effective Treatment of Isometric Resistance Training for Blood Pressure Control: A Narrative Review in Healthy Individuals and People with Cardiovascular Diseases.Journal of functional morphology and kinesiology · 2026Review
- Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study.Circulation · 2026Article
- Article
- Child Opportunity Index and Prevalence of Obesity and Hypertension in Adolescents with Congenital Heart Disease.Pediatric cardiology · 2026Article
- "Short-term prognosis of hypertensive emergencies and urgencies: second preliminary report of the ongoing Italian multicenter ERIDANO study".Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Adaptive Optics RTX1 Imaging for Early Detection of Retinal Vascular Remodeling in Hypertensive Retinopathy: A Review.Journal of clinical medicine · 2026Review
- The impact of body mass index and epicardial adipose tissue on left atrial function in hypertensive patients: a cardiac magnetic resonance feature tracking study.Quantitative imaging in medicine and surgery · 2026Article
- Artificial Intelligence-Driven Hypertension Management: Implications for Quality Improvement and Prevention of End-Organ Damage.Life (Basel, Switzerland) · 2026Review
- Albuminuria as a Key Factor Associated with Ambulatory Arterial Stiffness: A Hierarchical Multivariable Analysis.Journal of clinical medicine · 2026Article
- Review
- Stroke risk in patients with hypertensive retinopathy: a systematic review and meta-analysis.BMJ neurology open · 2026Article
- Hypertension and left ventricular geometry: Diagnosis, prognosis, and management.EXCLI journal · 2026Review
- Ankle-Brachial Index as a Predictor of Cardiovascular and Cerebrovascular Events in Hypertension: A Systematic Review.Research in heart yield and translational medicine · 2026Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGuidelines emphasize screening people with elevated BP for the presence of end-organ damage.
methodsWe characterized the prevalence, correlates, and prognosis of hypertension-mediated organ damage (HMOD) in the community-based Framingham Study. 7898 participants (mean age 51.6 years, 54% women) underwent assessment for the following HMOD: electrocardiographic and echocardiographic left ventricular hypertrophy, abnormal brain imaging findings consistent with vascular injury, increased carotid intima-media thickness, elevated carotid-femoral pulse wave velocity, reduced kidney function, microalbuminuria, and low ankle-brachial index. We characterized HMOD prevalence according to blood pressure (BP) categories defined by four international BP guidelines. Participants were followed up for incidence of cardiovascular disease.
resultsThe prevalence of HMOD varied positively with systolic BP and pulse pressure but negatively with diastolic BP; it increased with age, was similar in both sexes, and varied across BP guidelines based on their thresholds defining hypertension. Among participants with hypertension, elevated carotid-femoral pulse wave velocity was the most prevalent HMOD (40%-60%), whereas low ankle-brachial index was the least prevalent (<5%). Left ventricular hypertrophy, reduced kidney function, microalbuminuria, increased carotid intima-media thickness, and abnormal brain imaging findings had an intermediate prevalence (20%-40%). HMOD frequently clustered within individuals. On follow-up (median, 14.1 years), there were 384 cardiovascular disease events among 5865 participants with concurrent assessment of left ventricular mass, carotid-femoral pulse wave velocity, kidney function, and microalbuminuria. For every BP category above optimal (referent group), the presence of HMOD increased cardiovascular disease risk compared with its absence.
conclusionsThe prevalence of HMOD varies across international BP guidelines based on their different thresholds for defining hypertension. The presence of HMOD confers incremental prognostic information regarding cardiovascular disease risk at every BP category.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.