Evidence map›Paper›PMID 35138625›Full record

ArticleAdvances in experimental medicine and biology2021

Ion Channels in Anesthesia.

Wei Zhou, Zhonghui Guan

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wei ZhouDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA. wei.zhou@ucsf.edu.
Zhonghui GuanDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Regulation of Nerve Injury-induced Gene Expression in Neuropathic PainR01NS100801 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUAN, ZHONGHUI · 2017 to 2021
$1.7M
NINDS NIH HHS R01 NS100801
6 · The paper itself

Abstract

Ion channels play a pivotal role in anesthesia, including general and regional anesthesia. Two main classes of general anesthetics (GAs) are inhalational anesthetics, such as isoflurane, sevoflurane, and nitrous oxide; injectable anesthetics, such as propofol, etomidate, and ketamine. Besides hypnotic agents, muscle relaxants for immobility and opioids for analgesia are needed to achieve balanced anesthesia. Although our understanding of anesthesia is far from complete, recent studies have revealed the molecular interactions between anesthetic drugs and ion channels, particularly, the ligand-gated ion channels (LGICs). Ionotropic GABA

Indexed as

AnesthesiaAnesthetics, InhalationIon ChannelsIsofluranePropofolAnesthetics, InhalationIon ChannelsIsofluranePropofolAnestheticsCholinergic receptorsEtomidateGABAA receptorsGlutamate receptorsIsofluraneKetamineNitrous oxidePropofolSevofluraneTwo-pore-domain K+ channels

Identifiers

PMID35138625
OpenAlexW4211025356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.