Evidence map›Paper›PMID 35138475›Full record

ArticleEuropean child & adolescent psychiatry2023

Comparison of antipsychotic drug use among Dutch Youth before and after implementation of the Youth Act (2010-2019).

Y Bais, R A Hermans, C C M Schuiling-Veninga, H J Bos, S M Kloosterboer, B C M de Winter, M Simoons, G C Dieleman, M H J Hillegers, B C P Koch and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European child & adolescent psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Y BaisDepartment of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
R A HermansDepartment of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
C C M Schuiling-VeningaDepartment of Pharmacotherapy, Epidemiology and Economics, University of Groningen, Groningen, The Netherlands.
H J BosDepartment of Pharmacotherapy, Epidemiology and Economics, University of Groningen, Groningen, The Netherlands.
S M KloosterboerDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.
B C M de WinterDepartment of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
M SimoonsDepartment of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
G C DielemanDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.
M H J HillegersDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.
B C P KochDepartment of Hospital Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands.
B DierckxDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands. b.dierckx@erasmusmc.nl.
Erasmus MC · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Dutch law on youth care (the Youth Act) was implemented from 2015 onwards. One of the government's aims by implementing this new policy was de-medicalization of youths by separating youth mental healthcare from the rest of the healthcare system. A previous study conducted by our research group showed that prevalence rates of antipsychotic drug prescriptions stabilized among Dutch youth in the period 2005-2015, just before the introduction of the Youth Act. In our study, we aimed to describe antipsychotic drug use among Dutch children aged 0-19 years old before and after implementation of the Youth Act (2010-2019).

methodsWe analyzed prescription data of 7405 youths aged 0-19 years using antipsychotic drugs between 2010 and 2019, derived from a large Dutch community pharmacy-based prescription database (IADB.nl).

resultsPrevalence rates of antipsychotic drug use per thousand youths decreased significantly in youths aged 7-12 years old in 2019 compared to 2015 (7.9 vs 9.0 p < 0.05). By contrast, prevalence rates increased in adolescent females in 2019 compared to 2015 (11.8 vs 9.5 p < 0.05). Incidence rates increased significantly in adolescent youths in 2019 compared to 2015 (3.9 vs 3.0 p < 0.05), specifically among adolescent girls (4.2 per thousand in 2019 compared to 3.0 per thousand in 2015). Dosages in milligram declined for the most commonly prescribed antipsychotic drugs during the study period. The mean duration of antipsychotic drug use in the study period was 5.7 (95% CI 5.2-6.2) months.

conclusionDespite the aim of the Youth Act to achieve de-medicalization of youths, no clear reduction was observed in prevalence rates of antipsychotic drugs or treatment duration in all subgroups. Prevalence rates even increased in adolescent females.

Indexed as

Antipsychotic AgentsAdolescentAdultChildChild, PreschoolDatabases, FactualDrug PrescriptionsFemaleHumansIncidenceInfantInfant, NewbornPrevalenceYoung AdultAntipsychotic AgentsAntipsychoticsDosagesDuration of useIncidencePrevalenceYouth act

Identifiers

PMID35138475
PMCPMC10326153
OpenAlexW4210893994

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.