ArticleEuropean journal of pediatrics2022
Parvovirus B19 myocarditis in children: a diagnostic and therapeutic approach.
Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Parvovirus B19-associated myocarditis in children: A systematic review of clinical features, management and outcomes.European journal of clinical investigation · 2025Pooled it
- Clinical and Cardiac Magnetic Resonance Imaging Findings in Pediatric Patients with Recurrent Viral Myocarditis.Pediatric cardiology · 2026Article
- Clinical and virological impacts of human parvovirus B19 epidemics on fulminant myocarditis in childhood.BMC pediatrics · 2026Article
- Brugada Phenocopy in a Child With Parvovirus B19 Myocarditis.JACC. Case reports · 2025Article
- Regional outbreak of parvovirus B19 acute myocarditis in preschool children.Pediatric investigation · 2025Article
- Fulminant parvovirus B19 myocarditis in infants -report of three post-pandemic cases.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Successful Weaning off LVAD Support in an Infant by Pulmonary Artery Banding.The Thoracic and cardiovascular surgeon reports · 2025Article
- Parvovirus B19 infection in children: a comprehensive review of clinical manifestations and management.Italian journal of pediatrics · 2024Review
- Lymphocytic Myocarditis in Children with Parvovirus B19 Infection: Pathological and Molecular Insights.Biomedicines · 2024Article
- Erythema Infectiosum: A Narrative Review.Current pediatric reviews · 2024Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parvovirus B19 is one of the most frequent causes of pediatric myocarditis, associating high mortality rates or need for cardiac transplantation. The aim of this study is to describe the clinical course of Parvovirus B19 myocarditis in children with emphasis on the role of endomyocardial biopsy and cardiac magnetic resonance, and the use of an innovative therapeutic strategy. Eleven patients and 12 episodes of polymerase chain reaction (PCR)-confirmed Parvovirus B19 myocarditis were prospectively collected for 14 years. Diagnosis was confirmed either histopathologically or by magnetic resonance. A life-threatening clinical presentation is described, similar to previous series, but with 83.3% overall survival without transplantation. We also present a case of recurrent myocarditis, which is extraordinarily rare. Electrocardiographic patterns presented chiefly peaked p waves, low QRS voltages, and negative T waves on inferior or lateral leads. Endomyocardial biopsy is the gold standard diagnostic test; alternatively magnetic resonance could be a useful diagnostic tool. A good concordance between myocardial and blood PCRs was observed. Seven patients received treatment with corticosteroids and beta interferon and all underwent a significant cardiac function improvement.
conclusionA severe clinical presentation is reported, similar to previous reports but with better outcomes. Endomyocardial biopsy is the gold standard diagnostic test; alternatively magnetic resonance may be used. Both blood and myocardium PCR can be used in children to establish the microbiological etiology. Steroids with IFNß could be a useful therapeutic option, although further multicenter studies are needed to confirm these results. WHAT IS KNOWN: • Parvovirus B19 is one of the most frequent causes of myocarditis in children. It is associated with a fulminant clinical presentation. • Endomyocardial biopsy is the gold standard diagnostic test but it is an invasive procedure. WHAT IS NEW: • Myocarditis may recur in pediatrics, even it is extraordinarily rare. • IFNβ with steroids may be a useful therapeutic option to improve the outcomes.
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