ArticleDiabetologia2022
Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes.
Article in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 51 citations in OpenAlex.
- Evaluation of Diabetes Risk Models Applied to the Prediction of Incident Dysglycaemia in African and European Populations.Diabetes, obesity & metabolism · 2026Article
- Divergent complication patterns of type 2 diabetes in African individuals who are lean versus overweight or obese: a multi-cohort analysis.Diabetologia · 2026Article
- Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.BMJ open diabetes research & care · 2026Article
- Precision medicine in low-income settings and small island developing states.Nature reviews. Endocrinology · 2026Review
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- Reproducibility of the diagnosis of diabetes by the 1-hour oral glucose tolerance test is substantial.Diabetes research and clinical practice · 2026Article
- Improving Precision Diagnosis and Treatment of Diabetes in Low-Resource Settings in Africa Through Structured Clinical Phenotyping: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Lean, Non-Autoimmune Young-Onset Diabetes in Bangladesh: A Metabolically Obese Phenotype With Disproportionate Insulin Secretory Defect.Endocrinology, diabetes & metabolism · 2026Article
- Atypical diabetes subtypes in Black African populations.Diabetologia · 2026Review
- African immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment.BMJ open diabetes research & care · 2026Article
- Systematic screening reveals high rates of undiagnosed hypertension and diabetes among people living with HIV in Tanzania: a cross-sectional study.Tropical medicine and health · 2026Article
- Metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus in Tanzania: prevalence and predictors.BMC endocrine disorders · 2026Article
- Prevalence and correlates of diagnosed and undiagnosed diabetes mellitus among adults in rural Uganda during the COVID-19 pandemic: an evaluation of a community-based screening programme.International health · 2026Article
- Decoding type 5 diabetes using spatial omics: microarchitectural and molecular mechanisms of malnutrition-associated diabetes.Frontiers in endocrinology · 2026Review
- Non-autoimmune diabetes in young people from Assam, India: the PHENOEINDY-2 study.Diabetologia · 2025Article
- Undernutrition-Associated Diabetes Mellitus: Pathophysiology of a Global Problem.Physiology (Bethesda, Md.) · 2025Review
- Phenotypic and Genetic Diversity in Diabetes Across Populations.The Journal of clinical endocrinology and metabolism · 2025Review
- Incident type 2 diabetes and its risk factors in men and women aged 40-60 years from four sub-Saharan African countries: results from the AWI-Gen study.The Lancet. Global health · 2025Article
- A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction.Cardiovascular diabetology · 2025Article
- Lean diabetes: 20-year trends in its prevalence and clinical features among Korean adults.BMC public health · 2024Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
aims/hypothesisApparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with new-onset type 2 diabetes are limited in this population. This cross-sectional study aimed to perform a detailed clinical and metabolic characterisation of newly diagnosed adult patients with diabetes in Uganda, in order to compare features between lean and non-lean individuals.
methodsSocio-demographic, clinical, biophysical and metabolic (including oral glucose tolerance test) data were collected on 568 adult patients with newly diagnosed diabetes. Participants were screened for islet autoantibodies to exclude those with autoimmune diabetes. The remaining participants (with type 2 diabetes) were then classified as lean (BMI <25 kg/m
resultsThirty-four participants (6.4%) were excluded from analyses because they were positive for pancreatic autoantibodies, and a further 34 participants because they had incomplete data. For the remaining 500 participants, the median (IQR) age, BMI and HbA CONCLUSIONS/
interpretationApproximately one-third of participants with incident adult-onset non-autoimmune diabetes had BMI <25 kg/m
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