ArticleHuman molecular genetics2022
Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.
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Article in Human molecular genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Sex dependent genetic architecture of biochemically verified tobacco use.Psychiatry research · 2025Trial
- Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.Scientific reports · 2024Article
- Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity.British journal of cancer · 2024Article
- Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.Research square · 2024Article
- Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine.Environmental epigenetics · 2024Article
- CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity.Frontiers in genetics · 2023Article
- A Pilot Analysis of Circulating cfRNA Transcripts for the Detection of Lung Cancer.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
56 authors at 20 institutions in 14 countries.
Yafang LiInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Xiangjun XiaoInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Jianrong LiInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Jinyoung ByunInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Chao ChengInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City G1V 4G5, Canada.
James McKaySection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon 69372, France.
Demetrios AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850, USA.
Stephen LamDepartment of Integrative Oncology, University of British Columbia, Vancouver, BC V5Z 1L3, Canada.
Adonina TardonPublic Health Department, University of Oviedo, ISPA and CIBERESP, Asturias 33003, Spain.
Chu ChenProgram in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Stig E BojesenDepartment of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen 2600, Denmark.
Maria T LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850, USA.
Mattias JohanssonSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon 69372, France.
Angela RischThoraxklinik at University Hospital Heidelberg, Heidelberg 69126, Germany.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, 37099, Germany.
H-Erich WichmannInstitute of Medical Statistics and Epidemiology, Technical University Munich, 80333, Germany.
David C ChristianiDepartments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Gad RennertClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa 3436212, Israel.
Susanne ArnoldUniversity of Kentucky, Markey Cancer Center, Lexington, Kentucky 40536, USA.
Gary GoodmanSwedish Cancer Institute, Seattle, WA 98104, USA.
John K FieldInstitute of Translational Medicine, University of Liverpool, Liverpool L69 7BE, United Kingdom.
Michael P A DaviesInstitute of Translational Medicine, University of Liverpool, Liverpool L69 7BE, United Kingdom.
Sanjay S SheteDepartment of Biostatistics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Olle MelanderFaculty of Medicine, Lund University, Lund 22184, Sweden.
Hans BrunnströmFaculty of Medicine, Lund University, Lund 22184, Sweden.
Geoffrey LiuUniversity Health Network- The Princess Margaret Cancer Centre, Toronto, CA ON, M5G 2C1, Canada.
Rayjean J HungLuenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto ON, M5G 1X5, Canada.
Angeline S AndrewDepartments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, NH 03755, USA.
Lambertus A KiemeneyRadboud University Medical Center, Nijmegen 6525, The Netherlands.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, P.R. China.
Ryan SunDepartment of Biostatistics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Shan ZienolddinyNational Institute of Occupational Health, Oslo 0304, Norway.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå 901 87, Sweden.
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umeå 901 87, Sweden.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850, USA.
Dawn M TearePopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington 99202, USA.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center Nashville, TN 37232, USA.
Ann G SchwartzDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Ivan GorlovInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Kristen PurringtonKarmanos Cancer Institute, Detroit, MI 48201, USA.
Ping YangDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinics Rochester, MN, 55905, USA.
Yanhong LiuSection of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Younghun HanInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Joan E Bailey-WilsonNational Human Genome Research Institute, NIH, Baltimore, MD 20892, USA.
Susan M PinneyUniversity of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Diptasri MandalLouisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
James C WilleyCollege of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.
Colette GabaThe University of Toledo College of Medicine, Toledo, OH 43614, USA.
Paul BrennanSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon 69372, France.
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
INTEGRAL-ILCCO lung cancer consortium
Houston Institute for Clinical Research · USCentre international de recherche sur le cancer · FRThe University of Texas Health Science Center at Houston · USLund University · SENational Cancer Institute · USThe University of Texas MD Anderson Cancer Center · USUmeå University · SEUniversity of Liverpool · GBUniversity of Toledo · USBaylor College of Medicine · USCancer Center of Hawaii · USCarmel Medical Center · ILDan L Duncan Comprehensive Cancer CenterDartmouth College · USFred Hutch Cancer Center · USGerman Center for Lung Research · DEHarvard University · USLouisiana State University Health Sciences Center New Orleans · USMayo Clinic in Florida · USMoffitt Cancer Center · US
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MREPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MGenetic Epidemiology of CancerZIAHG200331 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$11.7MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MINFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8MSequencing Familial Lung CancerU01CA243483 · NCI · BAYLOR COLLEGE OF MEDICINE · PI AMOS, CHRISTOPHER I., PINNEY, SUSAN MENGEL · 2020 to 2022
$2.0MFernald Community Cohort: Research Resource for Environmental EpidemiologyR24ES028527 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 2018 to 2024
$2.0MGenetic interaction analysis involving oncogenesis-related genes in lung cancerR21CA235464 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LI, YAFANG · 2019 to 2020
$380kNCI NIH HHS P30 CA015083NCI NIH HHS P30 CA076292NCI NIH HHS R21 CA235464NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA243483NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA167462NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R24 ES028527World Health Organization 001
Abstract
Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.
Indexed as
Genome-Wide Association StudyLung NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansLungMalePolymorphism, Single Nucleotide
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