Evidence map›Paper›PMID 35138360›Full record

Trial reportEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2022

Prognostic factors of 10-year mortality after coronary artery bypass graft surgery: a secondary analysis of the arterial revascularization trial.

Suprateeka Talukder, Arnaldo Dimagli, Umberto Benedetto, Alastair Gray, Stephen Gerry, Belinda Lees, Łukasz Krzych, Mario Gaudino, David P Taggart, Marcus Flather and 1 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Suprateeka TalukderNorwich Medical School, University of East Anglia, Norwich, UK.ORCID 0000-0001-5745-4765
Arnaldo DimagliBristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, UK.ORCID 0000-0003-0055-8656
Umberto BenedettoBristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, UK.ORCID 0000-0002-7074-7949
Alastair GrayHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0003-0239-7278
Stephen GerryCentre of Statistics in Medicine, Botnar Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0003-4654-7311
Belinda LeesNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Łukasz KrzychDepartment of Anaesthesiology and Intensive Care, Medical University of Silesia, Katowice, Poland.
Mario GaudinoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA.ORCID 0000-0003-4680-0815
David P TaggartNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Marcus FlatherNorwich Medical School, University of East Anglia, Norwich, UK.ORCID 0000-0001-5644-3116
ART Investigators

Funding

British Heart Foundation SP/03/001Medical Research Council G0200390
6 · The paper itself

Abstract

objectivesThe objective of this investigation was to determine the preoperative prognostic factors of long-term (10-year) mortality in patients treated with isolated coronary artery bypass graft surgery in the arterial revascularization trial (ART).

methodsA post hoc analysis of the ART was conducted. Cumulative 10-year mortality was estimated using the Kaplan-Meier method. Prospectively collected preoperative data were used to determine the prognostic factors of 10-year all-cause mortality in patients who participated in the ART (Cox proportional hazards model).

resultsA total of 3102 patients who participated in the ART were included in the analysis. Ten-year follow-up was completed in 3040 patients (98%). A total of 644 patients (20.8%) had died by 10 years. Preoperative factors that were identified as statistically significant predictors of 10-year mortality in the multivariable analysis (all P ≤ 0.01) were: left ventricular ejection fraction, atrial fibrillation, age, diabetes, prior cerebrovascular event (stroke or transient ischaemic attack), serum creatinine and smoking status. The following variables were significantly associated in univariable models but did not retain significance in the multivariable model for mortality: non-Caucasian ethnicity, hypertension, peripheral vascular disease, chronic obstructive pulmonary disease and prior myocardial infarction.

conclusionsIndependent predictors of 10-year mortality in the ART were multifactorial. Several key independent predictors of 10-year mortality in the ART were identified including: heart function, renal function, cerebrovascular disease, age, atrial fibrillation, smoking status and diabetes. Understanding which preoperative variables influence long-term outcome after coronary artery bypass grafting may help to target treatments to those at higher risk to reduce mortality.

Indexed as

Atrial FibrillationCoronary Artery DiseaseDiabetes MellitusCoronary Artery BypassHumansPrognosisRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftARTMortalityPrognostic factors

Identifiers

PMID35138360
PMCPMC9154348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.