Evidence map›Paper›PMID 35138342›Full record

ArticleTranslational vision science & technology2022

Prospective Pilot Clinical Study of Noninvasive Cerebrovascular Autoregulation Monitoring in Open-Angle Glaucoma Patients and Healthy Subjects.

Yasin Hamarat, Mantas Deimantavicius, Vilius Dambrauskas, Vaidas Labunskas, Vilma Putnynaite, Paulius Lucinskas, Lina Siaudvytyte, Evelina Simiene, Akvile Stoskuviene, Ingrida Januleviciene and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. The role of RGC degeneration in the pathogenesis of glaucoma.International journal of biological sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yasin HamaratHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Mantas DeimantaviciusHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Vilius DambrauskasHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Vaidas LabunskasHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Vilma PutnynaiteHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Paulius LucinskasHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Lina SiaudvytyteEye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Evelina SimieneEye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Akvile StoskuvieneEye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ingrida JanulevicieneEye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vytautas PetkusHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Arminas RagauskasHealth Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.
Kaunas University of Technology · LTHospital of Lithuanian University of Health Sciences Kaunas Clinics · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the cerebrovascular autoregulation (CA) dynamics in patients with normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) as well as healthy subjects using noninvasive ultrasound technologies for the first time.

methodsThe CA status of 10 patients with NTG, 8 patients with HTG, and 10 healthy subjects was assessed, using an innovative noninvasive ultrasonic technique, based on intracranial blood volume slow-wave measurements. Identified in each participant were intraocular pressure, ocular perfusion pressure, and CA-related parameter volumetric reactivity index (VRx), as well as the duration and doses of the longest cerebral autoregulation impairment (LCAI). In addition, we calculated the associations of these parameters with patients' diagnoses.

resultsThe VRx value, the LCAI dose, and duration in healthy subjects were significantly lower than in patients with NTG (P < 0.05). However, no significant differences were noted in these parameters between healthy subjects and HTG and between NTG and HTG groups.

conclusionsNTG is associated with the disturbed cerebral blood flow and could be diagnosed by performing noninvasive CA assessments. TRANSLATIONAL RELEVANCE: The VRx monitoring method can be applied to a wider range of patient groups, especially patients with normal-tension glaucoma.

Indexed as

GlaucomaGlaucoma, Open-AngleLow Tension GlaucomaHealthy VolunteersHomeostasisHumansProspective Studies

Identifiers

PMID35138342
PMCPMC8842541
OpenAlexW4210861454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.