SynthesisJournal of medical Internet research2022
Attrition Within Digital Health Interventions for People With Multiple Sclerosis: Systematic Review and Meta-analysis.
Synthesis in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Ethical implications of high attrition in AI-based mental health interventions: a systematic review and meta-analysis.BMC medical ethics · 2026Pooled it
- Pooled it
- Dropout Rate of Participants in Randomized Clinical Trials That Use Virtual Reality to Train Balance and Gait in Parkinson's Disease. A Systematic Review With Meta-analysis and Meta-regression.Journal of medical systems · 2023Pooled it
- Dropout Rate in Digital Health Interventions for the Prevention of Skin Cancer: Systematic Review, Meta-analysis, and Metaregression.Journal of medical Internet research · 2022Pooled it
- Evaluating nurse-led self-regulation in multiple sclerosis management with an interactive web-based program: a randomized controlled trial.Health education research · 2026Trial
- A Web-Based Lifestyle-Related Course for People Living With Multiple Sclerosis: Quantitative Evaluation of Course Completion, Satisfaction, and Lifestyle Changes Among Participants Enrolled in a Randomized Controlled Trial.JMIR human factors · 2025Trial
- Sociodemographic, Health, and Lifestyle-Related Characteristics Associated With the Commencement and Completion of a Web-Based Lifestyle Educational Program for People With Multiple Sclerosis: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Evaluation of a web-based program for the adoption of wellness behaviors to self-manage fatigue and improve quality of life among people with multiple sclerosis: A randomized waitlist-control trial.Multiple sclerosis and related disorders · 2023Trial
- Effects of digital health interventions on self-care and quality of life in patients with an ostomy: A systematic review and meta-analysis.Asia-Pacific journal of oncology nursing · 2026Review
- Prediction of Adherence to an Online Wellness Program for People with Mobility Limitations: A Machine Learning Approach.Healthcare (Basel, Switzerland) · 2026Article
- Inclusive approaches to research and healthcare for nitrous oxide users: lessons from a longitudinal study.BMJ neurology open · 2026Article
- From implementation to discontinuation: multi-year experience with the multiple sclerosis performance test as a digital monitoring tool.Frontiers in digital health · 2025Article
- Real-world patterns in remote longitudinal study participation: A study of the Swiss Multiple Sclerosis Registry.PLOS digital health · 2024Article
- Systematic review and meta-analysis of standalone digital interventions for cognitive symptoms in people without dementia.NPJ digital medicine · 2024Article
- Technology and Human Support Systems in Decentralized Studies: A Participant-Centered Case Study in Cystic Fibrosis.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- A Novel Mobile App for Personalized Dietary Advice Leveraging Persuasive Technology, Computer Vision, and Cloud Computing: Development and Usability Study.JMIR formative research · 2023Article
- Study protocol for an online lifestyle modification education course for people living with multiple sclerosis: the multiple sclerosis online course (MSOC).BMC neurology · 2023Article
- Management of multiple sclerosis fatigue in the digital age: from assessment to treatment.Frontiers in neuroscience · 2023Review
- Feasibility and scalability of a fitness tracker study: Results from a longitudinal analysis of persons with multiple sclerosis.Frontiers in digital health · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDigital health interventions have revolutionized multiple sclerosis (MS) care by supporting people with MS to better self-manage their disease. It is now understood that the technological elements that comprise this category of digital health interventions can influence participant engagement in self-management programs, and people with MS can experience significant barriers, influenced by these elements, to remaining engaged during a period of learning. It is essential to explore the influence of technological elements in mitigating attrition.
objectiveThis study aimed to examine the study design and technological elements of documented digital health interventions targeted at people with MS-digital health interventions that were intended to support a program of engagement over a defined period-and to explore how these correlated with attrition among participants of randomized controlled trials (RCTs).
methodsWe conducted a systematic review and meta-analysis of RCTs (n=32) describing digital health self-management interventions for people with MS. We analyzed attrition in included studies, using a random-effects model and meta-regression to measure the association between potential moderators.
resultsThere were no measured differences in attrition between the intervention and control arms; however, some of the heterogeneity observed was explained by the composite technological element score. The pooled attrition rates for the intervention and control arms were 14.7% and 15.6%, respectively.
conclusionsThis paper provides insight into the technological composition of digital health interventions designed for people with MS and describes the degree of attrition in both study arms. This paper will aid in the design of future studies in this area, particularly for digital health interventions of this type.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.