Evidence map›Paper›PMID 35138124›Full record

ArticlemSphere2022

Gastric Non-Helicobacter pylori Urease-Positive Staphylococcus epidermidis and Streptococcus salivarius Isolated from Humans Have Contrasting Effects on H. pylori-Associated Gastric Pathology and Host Immune Responses in a Murine Model of Gastric Cancer.

Zeli Shen, JoAnn Dzink-Fox, Yan Feng, Sureshkumar Muthupalani, Anthony J Mannion, Alexander Sheh, Mark T Whary, Hilda R Holcombe, Blanca M Piazuelo, Luis E Bravo and 6 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Review
  3. Correlation analysis of gut microbiota and metabolites in gastric cancer patients in plateau areas based on multi-omics technologies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Whole genome sequences of novelMicrobiology resource announcements · 2026
    Article
  5. Review
  6. An Unusual Case ofInfection and drug resistance · 2026
    Article
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  9. Observational
  10. Article
  11. Review
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  15. Review
  16. The influence ofComputational and structural biotechnology journal · 2024
    Review
  17. Review
  18. Article
  19. Exploring the Link betweenAntibiotics (Basel, Switzerland) · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Zeli ShenDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
JoAnn Dzink-FoxDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Yan FengDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Sureshkumar MuthupalaniDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Anthony J MannionDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.ORCID 0000-0002-6112-0546
Alexander ShehDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Mark T WharyDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Hilda R HolcombeDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Blanca M PiazueloDivision of Gastroenterology, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA.
Luis E BravoDepartment of Pathology, Universidad del Valle, Cali, Colombia.
Christine JosenhansMedical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Ludwig Maximilians University, Munich, Germany.
Sebastian SuerbaumMedical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Ludwig Maximilians University, Munich, Germany.
Keith T WilsonDivision of Gastroenterology, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA.
Richard M PeekDivision of Gastroenterology, Vanderbilt University Medical Centergrid.412807.8, Nashville, Tennessee, USA.
Timothy C WangDivision of Gastroenterology and Irvine Cancer Research Center, Columbia Universitygrid.21729.3f, New York, New York, USA.
James G FoxDivision of Comparative Medicine, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.ORCID 0000-0001-9307-6116
Massachusetts Institute of Technology · USVanderbilt University Medical Center · USLudwig-Maximilians-Universität München · DECancer Research Center · USUniversidad del Valle · CO

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 2009 to 2026
$27.5M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Project 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8M
The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
H.Pylori Relationship to Digestive Diseases and CancerR01CA077955 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2003 to 2026
$9.7M
Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease ProgressionI01CX002171 · VA · VETERANS HEALTH ADMINISTRATION · PI Keith T. Wilson · 2020 to 2026
–
CSRD VA I01 CX002171NCI NIH HHS P01 CA028842NCI NIH HHS P01 CA116087NCI NIH HHS R01 CA077955NCI NIH HHS R35 CA210088NIDDK NIH HHS P30 DK058404NIEHS NIH HHS P30 ES002109
6 · The paper itself

Abstract

In populations with similar prevalence of Helicobacter pylori infection, cancer risk can vary dramatically. Changes in composition or structure of bacterial communities in the stomach, either at the time of exposure or over the course of H. pylori infection, may contribute to gastric pathology. In this study, a population of 37 patients from the low-gastric-cancer-risk (LGCR) region of Tumaco, Colombia, and the high-gastric-cancer-risk (HGCR) region of Túquerres, Colombia, were recruited for gastric endoscopy. Antral biopsy specimens were processed for histology and bacterial isolation. Fifty-nine distinct species among 26 genera were isolated by aerobic, anaerobic, and microaerobic culture and confirmed by 16S rRNA analysis. Urease-positive Staphylococcus epidermidis and Streptococcus salivarius were frequently isolated from gastric biopsy specimens. We asked whether coinfection of H. pylori with urease-positive

Indexed as

CoinfectionHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsStreptococcus salivariusAnimalsCytokinesDisease Models, AnimalHumansImmunityMiceRNA, Ribosomal, 16SStaphylococcus epidermidisUreaseCytokinesRNA, Ribosomal, 16SUreaseH. pyloriINS-GAS micemicrobiomeS. epidermidisS. salivarius

Identifiers

PMID35138124
PMCPMC8826947
OpenAlexW4210833434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.