ArticleJournal of the American Chemical Society2022
Catalytic Activation of Unstrained C(Aryl)-C(Alkyl) Bonds in 2,2'-Methylenediphenols.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Catalytic C-Demethylation of Phenols and Anilines Enabled by a Removable Mono-Directing Group.Journal of the American Chemical Society · 2026Article
- Hydrogen transfer-triggered C(spNature communications · 2026Article
- CYP3A Mediates an Unusual C(spAngewandte Chemie (International ed. in English) · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Catalytic activation of unstrained and nonpolar C-C bonds remains a largely unmet challenge. Here, we describe our detailed efforts in developing a rhodium-catalyzed hydrogenolysis of unstrained C(aryl)-C(alkyl) bonds in 2,2'-methylenediphenols aided by removable directing groups. Good yields of the monophenol products are obtained with tolerating a wide range of functional groups. In addition, the reaction is scalable, and the catalyst loading can be reduced to as low as 0.5 mol %. Moreover, this method proves to be effective to cleave C(aryl)-C(alkyl) linkages in both models of phenolic resins and commercial novolacs resins. Finally, detailed experimental and computational mechanistic studies show that with C-H activation being a competitive but reversible off-cycle reaction, this transformation goes through a directed C(aryl)-C(alkyl) oxidative addition pathway.
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Registered trials
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