Evidence map›Paper›PMID 35137689›Full record

ArticleeLife2022

Differences in local immune cell landscape between Q fever and atherosclerotic abdominal aortic aneurysms identified by multiplex immunohistochemistry.

Kimberley R G Cortenbach, Alexander H J Staal, Teske Schoffelen, Mark A J Gorris, Lieke L Van der Woude, Anne F M Jansen, Paul Poyck, Robert Jan Van Suylen, Peter C Wever, Chantal P Bleeker-Rovers and 6 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Kimberley R G Cortenbach *Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-2717-5527
Alexander H J Staal *Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Teske SchoffelenDepartment of Internal Medicine, Division of Infectious Diseases and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands.
Mark A J GorrisDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Lieke L Van der WoudeDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Anne F M JansenDepartment of Internal Medicine, Division of Infectious Diseases and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands.
Paul PoyckDepartment of Surgery, Radboud University Medical Centre, Nijmegen, Netherlands.
Robert Jan Van SuylenDepartment of Pathology, Jeroen Bosch Ziekenhuis, 's Hertogenbosch, Netherlands.
Peter C WeverDepartment of Medical Microbiology and Infection Control, Jeroen Bosch Ziekenhuis, 's Hertogenbosch, Netherlands.
Chantal P Bleeker-RoversDepartment of Internal Medicine, Division of Infectious Diseases and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands.
Mangala SrinivasDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Konnie M HebedaDepartment of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID 0000-0002-4181-3302
Marcel van DeurenDepartment of Internal Medicine, Division of Infectious Diseases and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands.
Jos W Van der MeerDepartment of Internal Medicine, Division of Infectious Diseases and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands.
Jolanda M De VriesDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Roland R J Van KimmenadeDepartment of Cardiology, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID 0000-0002-8207-8906
Radboud University Nijmegen · NLJeroen Bosch Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic Q fever is a zoonosis caused by the bacterium Methods: Multiplex immunohistochemistry was used to investigate local inflammation in Q fever AAAs compared to atherosclerotic AAAs in aorta tissue specimen. Two six-plex panels were used to study both the innate and adaptive immune systems. Results: Q fever AAAs and atherosclerotic AAAs contained similar numbers of CD68 Conclusions: These findings demonstrate that despite the presence of pro-inflammatory effector cells, persistent local infection with Funding: This work was supported by SCAN consortium: European Research Area - CardioVascualar Diseases (ERA-CVD) grant [JTC2017-044] and TTW-NWO open technology grant [STW-14716].

Indexed as

Adaptive ImmunityAgedAortic Aneurysm, AbdominalAtherosclerosisFemaleHumansImmunity, InnateImmunohistochemistryInflammationMacrophagesMaleMiddle AgedQ FeverT-Lymphocytesaortic aneurysmhumaninflammationmedicinemultiplex immunohistochemistryQ fever

Identifiers

PMID35137689
PMCPMC8871373
OpenAlexW4210933143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.