Evidence map›Paper›PMID 35137686›Full record

ArticleeLife2022

Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE.

Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Miaomiao LiDepartment of Oral Biology, University at Buffalo, State University of New York, Buffalo, United States.
Chih Yean OngDepartment of Oral Biology, University at Buffalo, State University of New York, Buffalo, United States.
Christophe J Langouët-AstriéDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States.
Lisi TanDepartment of Oral Biology, University at Buffalo, State University of New York, Buffalo, United States.
Ashwni VermaDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, United States.ORCID 0000-0003-3717-0233
Yimu YangDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States.
Xiaoxiao ZhangDepartment of Oral Biology, University at Buffalo, State University of New York, Buffalo, United States.ORCID 0000-0003-1321-0798
Dhaval K ShahDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, United States.
Eric P SchmidtDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States.
Ding XuDepartment of Oral Biology, University at Buffalo, State University of New York, Buffalo, United States.ORCID 0000-0001-9380-2712
University at Buffalo, State University of New York · USUniversity of Colorado Anschutz Medical Campus · US

Funding

In vitro synthesis of recombinant heparan sulfateR01HL094463 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN, PAWLINSKI, RAFAL L · 2009 to 2021
$5.2M
Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathyR01GM125095 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S, SCHMIDT, ERIC PETER · 2017 to 2020
$1.9M
Pharmacokinetic strategies to increase monoclonal antibody uptake, distribution, and efficacy for treatment of solid tumorsR01CA246785 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BALTHASAR, JOSEPH P, SHAH, DHAVAL K · 2020 to 2024
$1.8M
Heparan Sulfate–Osteoprotegerin Interactions in Bone RemodelingR01AR070179 · NIAMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI XU, DING · 2017 to 2021
$1.7M
Translational Systems Pharmacokinetic Models of Novel Anticancer BiologicsR01GM114179 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SHAH, DHAVAL K · 2015 to 2019
$1.7M
Modulation of antigen pharmacokinetics with pH dependent antibodyR21AI138195 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PARK, SHELDON · 2018 to 2019
$425k
NCI NIH HHS R01 CA246785NHLBI NIH HHS R01 HL094463NIAID NIH HHS R21 AI138195NIAMS NIH HHS R01 AR070179NIGMS NIH HHS R01 GM114179NIGMS NIH HHS R01 GM125095
6 · The paper itself

Abstract

RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. To understand the physiological significance of HS-induced RAGE oligomerization in vivo, we generated RAGE knock-in mice (

Indexed as

AnimalsCHO CellsCricetinaeCricetulusHeparan SulfateHumansMiceMice, KnockoutMice, TransgenicModels, MolecularOsteoblastsOsteoclastsProtein ConformationReceptor for Advanced Glycation End ProductsAger protein, mouseHeparan SulfateReceptor for Advanced Glycation End Productscell biologyheparan sulfateimmunologyinflammationmouseoligomerizationosteoclastRAGE

Identifiers

PMID35137686
PMCPMC8863369
OpenAlexW4220661591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.