Evidence map›Paper›PMID 35137587›Full record

ArticleInorganic chemistry2022

Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for

Joshua J Woods, Ryan Unnerstall, Abbie Hasson, Diane S Abou, Valery Radchenko, Daniel L J Thorek, Justin J Wilson

Open access · greenAbstract read
In one paragraph

Article in Inorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Enhanced Thermodynamic Stability of UOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Rapid Elution ofMolecules (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Joshua J WoodsDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0002-6213-4093
Ryan UnnerstallDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Abbie HassonProgram in Quantitative Molecular Therapeutics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Diane S AbouDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Valery RadchenkoLife Science Division, TRIUMF, Vancouver, British Columbia V6T 2A3, Canada.
Daniel L J ThorekDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0002-4086-7982
Washington University in St. Louis · USCornell University · USTRIUMF · CA

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
The Radium-223 Combination Therapy Space; Improving Response and Clarifying ToxicitiesR01CA240711 · NCI · WASHINGTON UNIVERSITY · PI MICHALSKI, JEFF M., THOREK, DANIEL LYNDON JAFFE · 2020 to 2024
$2.2M
Opening the Therapeutic Window for PSMA-Targeted Molecular RadiotherapyR01CA229893 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2019 to 2024
$1.9M
Kallikrein-Targeted Alpha-Particle Therapy of Late-Stage Prostate CancerR01CA201035 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2017 to 2020
$1.4M
Chelation strategies for s-, p-, and f-block radionuclides for targeted alpha therapyR01EB029259 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2020 to 2023
$1.4M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA201035NCI NIH HHS R01 CA229893NCI NIH HHS R01 CA240711NIBIB NIH HHS R01 EB029259
6 · The paper itself

Abstract

Uranium-230 is an α-emitting radionuclide with favorable properties for use in targeted α-therapy (TAT), a type of nuclear medicine that harnesses α particles to eradicate cancer cells. To successfully implement this radionuclide for TAT, a bifunctional chelator that can stably bind uranium in vivo is required. To address this need, we investigated the acyclic ligands H

Indexed as

Alpha ParticlesChelating AgentsUraniumAnimalsCoordination ComplexesDensity Functional TheoryHumansLigandsMiceModels, MolecularMolecular StructureChelating AgentsCoordination ComplexesLigandsUranium

Identifiers

PMID35137587
PMCPMC9382226
OpenAlexW4210930589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.