Evidence map›Paper›PMID 35137570›Full record

Observational studyESC heart failure2022

Prognostic significance of serum chloride level in heart failure patients with preserved ejection fraction.

Masahiro Seo, Tetsuya Watanabe, Takahisa Yamada, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Shunsuke Tamaki, Yoshio Yasumura, Yohei Sotomi and 5 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Masahiro SeoDivision of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan.
Tetsuya WatanabeDivision of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan.
Takahisa YamadaDivision of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan.
Masamichi YanoDivision of Cardiology, Osaka Rosai Hospital, Osaka, Japan.
Takaharu HayashiDivision of Cardiology, Osaka Police Hospital, Osaka, Japan.
Akito NakagawaDivision of Cardiovascular Medicine, Amagasaki-Chuo Hospital, Amagasaki, Japan.
Yusuke NakagawaDivision of Cardiology, Kawanishi City Hospital, Kawanishi, Japan.
Shunsuke TamakiDepartment of Cardiology, Rinku General Medical Center, Osaka, Japan.
Yoshio YasumuraDivision of Cardiovascular Medicine, Amagasaki-Chuo Hospital, Amagasaki, Japan.
Yohei SotomiDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Shungo HikosoDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Daisaku NakataniDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Masatake FukunamiDivision of Cardiology, Osaka General Medical Center, 3-1-56 Mandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan.
Yasushi SakataDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Osaka CardioVascular Conference (OCVC)-Heart Failure investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe prognostic value of serum chloride level has been reported primarily in patients with heart failure with reduced ejection fraction, and hence, there is limited evidence in patients of heart failure with preserved ejection fraction (HFpEF). This study was conducted to clarify the relationship between serum chloride level and clinical outcomes in patients with HFpEF with acute decompensated heart failure (ADHF). METHODS AND

resultsPatient data were extracted from The Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFpEF) study, a prospective multicentre observational registry for ADHF-HFpEF in Osaka. The data of 870 patients were analysed after excluding patients with in-hospital death, missing follow-up data, missing data of serum chloride level, or on chronic dialysis therapy. The primary endpoint of this study was all-cause mortality. At discharge, right ventricular systolic dysfunction was significantly associated with the lowest tertile of serum chloride level after multivariable adjustment (P = 0.0257). During a mean follow-up period of 1.8 ± 1.0 years, 186 patients died. Cox multivariable analysis showed that serum chloride level at discharge (P = 0.0017) was independently associated with all-cause mortality after multivariable adjustment of major confounders, whereas serum sodium level was no longer significant (P = 0.6761). Kaplan-Meier survival curve analysis revealed a significantly increased risk of mortality stratified by the tertile of serum chloride level [29% vs. 19% vs. 16%, P = 0.0002; hazard ratio (HR): 2.09 (95% confidence interval, CI: 1.31 to 3.34), HR: 1.03 (95% CI: 0.65 to 1.64)].

conclusionsSerum chloride level was useful for the prediction of poor outcome in ADHF patients with preserved ejection fraction.

Indexed as

ChloridesHeart FailureHospital MortalityHumansPrognosisProspective StudiesStroke VolumeChloridesHeart failure with preserved ejection fractionRisk stratificationSerum chloride level

Identifiers

PMID35137570
PMCPMC8934985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.