Evidence map›Paper›PMID 35137561›Full record

ArticleBrain and behavior2022

Neuropsychological deficits in patients with cognitive complaints after COVID-19.

Carmen García-Sánchez, Marco Calabria, Nicholas Grunden, Catalina Pons, Juan Antonio Arroyo, Beatriz Gómez-Anson, Alberto Lleó, Daniel Alcolea, Roberto Belvís, Noemí Morollón and 3 more

Abstract read
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Neurocognitive Impairment in Long COVID: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Pooled it
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  4. COVID-19 associated cognitive impairment: A systematic review.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Pooled it
  5. Profiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carmen García-SánchezNeuropsychology Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0001-5672-9229
Marco CalabriaFaculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain.ORCID 0000-0003-4373-1316
Nicholas GrundenDepartment of Psychology, Concordia University, Montreal, Canada.ORCID 0000-0002-7724-4316
Catalina PonsFacultat de Psicologia, Ciències de l'Educació i l'Esport, Blanquerna, Universitat Ramon Llull, Barcelona, Spain.
Juan Antonio ArroyoInternal Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Beatriz Gómez-AnsonNeurodiagnostic Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Alberto LleóMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Daniel AlcoleaMemory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Roberto BelvísHeadache Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Noemí MorollónHeadache Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Isabel MurInfectious Disease Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Virginia PomarInfectious Disease Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Pere DomingoInfectious Disease Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID 0000-0003-1138-5770

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile much of the scientific focus thus far has been on cognitive sequelae in patients with severe COVID-19, subjective cognitive complaints are being reported across the spectrum of disease severity, with recent studies beginning to corroborate patients' perceived deficits. In response to this, the aims of this study were to (1) explore the frequency of impaired performance across cognitive domains in post-COVID patients with subjective complaints and (2) uncover whether impairment existed within a single domain or across multiple.

methodsSixty-three patients with subjective cognitive complaints post-COVID were assessed with a comprehensive protocol consisting of various neuropsychological tests and mood measures. Cognitive test performance was transformed into T scores and classified based on recommended guidelines. After performing a principal component analysis to define cognitive domain factors, distributions of test scores within and across domains were analyzed.

resultsResults revealed pervasive impact on attention abilities, both as the singularly affected domain (19% of single-domain impairment) as well as coupled with decreased performance in executive functions, learning, and long-term memory. These salient attentional and associated executive deficits were largely unrelated to clinical factors such as hospitalization, disease duration, biomarkers, or affective measures. DISCUSSION: These findings stress the importance of comprehensive evaluation and intervention to address cognitive sequelae in post-COVID patients of varying disease courses, not just those who were hospitalized or experienced severe symptoms. Future studies should investigate to what extent these cognitive abilities are recuperated over time as well as employ neuroimaging techniques to uncover underlying mechanisms of neural damage.

Indexed as

Cognition DisordersCognitive DysfunctionCOVID-19CognitionExecutive FunctionHumansNeuropsychological Testscognitioncognitive complaintsneuropsychologypost-COVID-19

Identifiers

PMID35137561
PMCPMC8933779

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.