Evidence map›Paper›PMID 35137472›Full record

ReviewJournal of internal medicine2022

Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?

Nils Bomer, Mario G Pavez-Giani, Niels Grote Beverborg, John G F Cleland, Dirk J van Veldhuisen, Peter van der Meer

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Cuproptosis: potential new direction in liver-related diseases research and treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  9. Observational
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  16. Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Observational
  17. Review
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nils BomerDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-5926-6960
Mario G Pavez-GianiDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-3330-9384
Niels Grote BeverborgDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
John G F ClelandRobertson Centre for Biostatistics and Clinical Trials, University of Glasgow, Glasgow, UK.
Dirk J van VeldhuisenDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
Peter van der MeerDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-9705-4413
University Medical Center Groningen · NLHarefield Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure is a devastating clinical syndrome, but current therapies are unable to abolish the disease burden. New strategies to treat or prevent heart failure are urgently needed. Over the past decades, a clear relationship has been established between poor cardiac performance and metabolic perturbations, including deficits in substrate uptake and utilization, reduction in mitochondrial oxidative phosphorylation and excessive reactive oxygen species production. Together, these perturbations result in progressive depletion of cardiac adenosine triphosphate (ATP) and cardiac energy deprivation. Increasing the delivery of energy substrates (e.g., fatty acids, glucose, ketones) to the mitochondria will be worthless if the mitochondria are unable to turn these energy substrates into fuel. Micronutrients (including coenzyme Q10, zinc, copper, selenium and iron) are required to efficiently convert macronutrients to ATP. However, up to 50% of patients with heart failure are deficient in one or more micronutrients in cross-sectional studies. Micronutrient deficiency has a high impact on mitochondrial energy production and should be considered an additional factor in the heart failure equation, moving our view of the failing myocardium away from an "an engine out of fuel" to "a defective engine on a path to self-destruction." This summary of evidence suggests that supplementation with micronutrients-preferably as a package rather than singly-might be a potential therapeutic strategy in the treatment of heart failure patients.

Indexed as

Heart FailureMalnutritionAdenosine TriphosphateCross-Sectional StudiesEnergy MetabolismHumansMicronutrientsMitochondriaMyocardiumAdenosine TriphosphateMicronutrientsdeficiencyheart failuremicronutrientsmitochindrial dysfunction

Identifiers

PMID35137472
PMCPMC9303299
OpenAlexW4210885629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.