ArticleActa paediatrica (Oslo, Norway : 1992)2022
Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children.
Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 20 citations in OpenAlex.
- Attenuated Seasonality of Childhood Type 1 Diabetes with Increasing Autoimmune Comorbidities: A 40-year Cohort Study.Irish journal of medical science · 2026Article
- Seasonal Variation of Diabetic Ketoacidosis among Children and Adolescents with Type 1 Diabetes:Saudi medical journal · 2026Article
- Epidemiological Trends and Seasonal Patterns in Childhood Type 1 Diabetes: Insights From 2001 to 2024 in Lithuania.Pediatric diabetes · 2026Article
- Evaluation of distinct and similar pathological features between diabetes and Alzheimer's disease.EXCLI journal · 2026Review
- Clustering patterns in Finnish type 1 diabetes patients: a nationwide register-based study.BMJ open diabetes research & care · 2025Article
- Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review).Molecular medicine reports · 2025Review
- Global, regional, and national epidemiology of type 1 diabetes in children from 1990 to 2021: trend and health inequality analyses based on the Global Burden of Disease Study 2021.Diabetology & metabolic syndrome · 2025Article
- Type 1 Diabetes: A Guide to Autoimmune Mechanisms for Clinicians.Diabetes, obesity & metabolism · 2025Review
- Seasonal Patterns in Erectile Dysfunction Severity.Cureus · 2025Article
- Seasonal Variation in Type 1 Diabetes Incidence in Poland: Exploring the Impact of Viral Infections, Including COVID-19.Pediatric diabetes · 2025Article
- Grape Seed Proanthocyanidin Extract Attenuates Cafeteria-Diet-Induced Liver Metabolic Disturbances in Rats: Influence of Photoperiod.International journal of molecular sciences · 2024Article
- The COVID-19 Pandemic Increased the Incidence of New-Onset Type One Diabetes in Children.Children (Basel, Switzerland) · 2024Article
- Ten-year review of trends in children with type 1 diabetes in England and Wales.World journal of diabetes · 2023Review
- Antidiabetic Properties of Plant Secondary Metabolites.Metabolites · 2023Review
- Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
aimWe tested the hypothesis of a more aggressive disease process at diagnosis of type 1 diabetes during fall and winter, the colder seasons with consistently observed higher incidence of type 1 diabetes.
methodsSeasonality in the manifestation of type 1 diabetes was examined in 4993 Finnish children and adolescents. Metabolic characteristics, beta-cell autoantibodies and HLA class II genetics were analysed at clinical diagnosis.
resultsSignificant seasonality was observed with higher number of new cases during fall and winter (n = 1353/27.1% and n = 1286/25.8%) compared with spring and summer (n = 1135/22.7% and n = 219/24.4%) (p < 0.001). The youngest children (aged 0.5-4 years) differed from the older ones (aged 5-14 years) as a minority of them were diagnosed in winter (p = 0.019) while the older children followed the same pattern as that seen in the total series. Poorer metabolic decompensation was observed during seasons with lower number of new diagnoses.
conclusionThe heterogeneity in the seasonality of diabetes manifestation between younger and older children suggests that different environmental factors may trigger the disease at different ages. Poorer clinical condition associated with seasons with a lower number of new cases may be more likely to be due to a delay in seeking medical help than to a more aggressive autoimmunity.
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