Evidence map›Paper›PMID 35137345›Full record

Trial reportClinical drug investigation2022

Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women.

Milko Radicioni, Chiara Leuratti, Barbara Cometti

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical drug investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03735030 (Comparative Bioavailability Study of Choriomon®), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03735030 phase1completednot on this map

Comparative Bioavailability Study of Choriomon® (IBSA) Versus a Marketed hCG Formulation, Following Subcutaneous Administration in Healthy Women. Single-dose, Open-label, Randomized, Two-period, Two-way Cross-over, Bioavailability Study

TypeinterventionalSponsorIBSA Institut Biochimique SARan2018 to 2019Enrolled26ConditionsInfertilityArmsHuman hCG 10'000 IU, Recombinant hCG 6'500 IU
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Milko RadicioniCROSS Research S.A., Clinical Phase I Unit, Via F.A. Giorgioli 14, 6864, Arzo, Switzerland.ORCID http://orcid.org/0000-0002-3940-8375
Chiara LeurattiCROSS Research S.A., Clinical Projects Unit, Via L. Lavizzari 18, 6850, Mendrisio, Switzerland. chiara.leuratti@croalliance.com.ORCID http://orcid.org/0000-0001-5594-6029
Barbara ComettiIBSA Institut Biochimique S.A., Via del Piano, 6915, Pambio-Noranco, Switzerland.ORCID http://orcid.org/0000-0002-0810-7676
IBSA Institut Biochimique (Switzerland) · CHOrganizzazione Sociopsichiatrica Cantonale · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesExogenous human chorionic gonadotropin (hCG) acts on the final phase of the follicle maturation. Choriomon

methodsIn this randomized, two-way cross-over study, 26 healthy women received a single dose of Choriomon

resultsSerum hCG concentrations increased rapidly with a very similar pharmacokinetic curve for the two products. The test/reference geometric means ratio (GMR) for AUC

conclusionsThe differences between Choriomon CLINICALTRIALS: GOV REGISTRATION NO: NCT03735030.

Indexed as

Chorionic GonadotropinArea Under CurveBiological AvailabilityCross-Over StudiesFemaleHumansTherapeutic EquivalencyChorionic Gonadotropin

Identifiers

PMID35137345
PMCPMC8930902
OpenAlexW4210901528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.