Evidence map›Paper›PMID 35137261›Full record

ArticleBioprocess and biosystems engineering2022

Yeast-based production and in situ purification of acetaldehyde.

Hendrik G Mengers, William Graf von Westarp, Daniela Brücker, Andreas Jupke, Lars M Blank

Open access · hybridAbstract read
In one paragraph

Article in Bioprocess and biosystems engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hendrik G MengersInstitute of Applied Microbiology - iAMB, Aachener Biologie und Biotechnologie - ABBt, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-5098-164X
William Graf von WestarpFluid Process Engineering (AVT.FVT), RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-6137-8942
Daniela BrückerInstitute of Applied Microbiology - iAMB, Aachener Biologie und Biotechnologie - ABBt, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0001-6154-6515
Andreas JupkeFluid Process Engineering (AVT.FVT), RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0001-6551-5695
Lars M BlankInstitute of Applied Microbiology - iAMB, Aachener Biologie und Biotechnologie - ABBt, RWTH Aachen University, Aachen, Germany. lars.blank@rwth-aachen.de.ORCID http://orcid.org/0000-0003-0961-4976
RWTH Aachen University · DE

Funding

Deutsche Forschungsgemeinschaft 390919832
6 · The paper itself

Abstract

Acetaldehyde is a platform chemical with a production volume of more than 1 Mt/a, but is chiefly synthesized from petrochemical feedstocks. We propose the fermentative conversion of glucose towards acetaldehyde via genetically modified S. cerevisiae. This allows for ethanol-free bioactaldehyde production. Exploiting the high volatility of the product, in situ gas stripping in an aerated reactor is inevitable and crucial due to the respiratory toxicity effects of the acetaldehyde overproduction. We devise a lab-scale setup for the recovery of the product from the off-gas. Water was chosen as a suitable solvent and the Henry coefficient of acetaldehyde in water was validated experimentally. Based on an experimentally verified capture efficiency of 75%, an acetaldehyde production rate of over 100 mg/g/h was reached in 200 mL lab-scale fermentations.

Indexed as

AcetaldehydeSaccharomyces cerevisiaeEthanolFermentationGlucoseAcetaldehydeEthanolGlucoseAbsorptionAcetaldehydeIn situ gas strippingRedox balanceS. cerevisiae

Identifiers

PMID35137261
PMCPMC8948146
OpenAlexW4210837899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.