Evidence map›Paper›PMID 35137248›Full record

ArticlePsychopharmacology2022

Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task.

Andrea E Moran, Y Wendy Huynh, Andrew P Finkner, Carly Selleck, Aelyn Thompson, Scott T Barrett, Rick A Bevins

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Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Andrea E MoranDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Y Wendy HuynhDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Andrew P FinknerDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Carly SelleckDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Aelyn ThompsonDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Scott T BarrettDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Rick A BevinsDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. rbevins1@unl.edu.

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
Interoceptive conditioning with nicotine: Changes in abuse liabilityR01DA046109 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2018 to 2022
$1.8M
Pharmacological interventions to diminish nicotine associated respondingR01DA034389 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2012 to 2016
$1.4M
NIH HHS DA034389NIH HHS DA046109NIH HHS GM130461
6 · The paper itself

Abstract

rationaleBupropion is a non-nicotine medication for smoking cessation that has overlapping stimulus effects with nicotine as demonstrated in drug discrimination studies. Whether these shared stimulus effects will alter acquisition or maintenance of a discrimination between nicotine and bupropion is unknown.

objectiveWe sought to test this possibility using the drug discriminated goal-tracking (DGT) task and whether discrimination training history affected generalization and substitution tests.

methodsSixty adult Sprague-Dawley rats (30M/30F) were equally split into three discrimination training groups: SAL-0.4NIC, 10BUP-0.4NIC, and 20BUP-0.4NIC. On nicotine days, all rats were administered subcutaneously 0.4 mg/kg nicotine and had intermittent access to liquid sucrose. On intermixed non-reinforced days, rats were administered intraperitoneally saline, 10 or 20 mg/kg bupropion. Upon completion, a range of nicotine and bupropion doses were assessed before substitution tests with varenicline and sazetidine-A were conducted.

resultsThe SAL-0.4NIC and 10BUP-0.4NIC groups readily discriminated by session 8, as evidenced by increased dipper entries (goal-tracking) on nicotine days. The 20BUP-0.4NIC group was slower to acquire the discrimination. Female rats, regardless of group, had higher conditioned responding evoked by the lowest dose of nicotine (0.025 mg/kg) in the dose-effect curve. The discrimination required rats to learn to withhold responding to the training dose of bupropion. This withholding of excitatory dipper entries generalized to other doses. Varenicline and sazetidine-A partially substituted for the nicotine stimulus, and this pattern did not differ with training history.

conclusionsWe are the first to study a drug-drug discrimination using the DGT task. Females appeared to have a lower discrimination threshold for nicotine that was not impacted by the learning history. Further work on the importance of sex as a biological variable and how the complex interoceptive stimulus effects of nicotine can vary with training histories is needed.

Indexed as

BupropionNicotineAnimalsDiscrimination LearningDose-Response Relationship, DrugFemaleGoalsNicotinic AgonistsRatsRats, Sprague-DawleyBupropionNicotineNicotinic AgonistsBupropionDrug discriminationInteroceptionNicotinePavlovian conditioningSazetidine-AStimulus effectsVareniclineZyban

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PMID35137248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.