Evidence map›Paper›PMID 35137117›Full record

ArticleThe Journal of antimicrobial chemotherapy2022

Are infants exposed to antimicrobials during the first 3 months of life at increased risk of recurrent use? An explorative data-linkage study.

Christian Magnus Thaulow, Stig Harthug, Roy Miodini Nilsen, Beate Horsberg Eriksen, Jannicke Slettli Wathne, Dag Berild, Hege Salvesen Blix

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Christian Magnus ThaulowDepartment of Clinical Science, University of Bergen, PO Box 7804, 5020, Bergen, Norway.ORCID 0000-0002-1965-3410
Stig HarthugDepartment of Clinical Science, University of Bergen, PO Box 7804, 5020, Bergen, Norway.
Roy Miodini NilsenFaculty of Health and Social Sciences, Western Norway University of Applied Sciences, PO Box 7030, 5020, Bergen, Norway.
Beate Horsberg EriksenDepartment of Paediatrics and Adolescence Medicine, Ålesund Hospital, PO Box 1600, 6026, Ålesund, Norway.
Jannicke Slettli WathneDepartment of Quality and Development, Hospital Pharmacies Enterprises in Western Norway, PO Box 1400, 5021, Bergen, Norway.ORCID 0000-0002-0828-2909
Dag BerildDepartment of Clinical Medicine, University of Oslo, PO Box 1077, 0316, Oslo, Norway.
Hege Salvesen BlixDepartment of Pharmacy, University of Oslo, PO Box 1068 Blindern, 0316, Oslo, Norway.
Haukeland University Hospital · NOÅlesund Hospital · NONorwegian Institute of Public Health · NOUniversity of Oslo · NOWestern Norway University of Applied Sciences · NO

Funding

C.M.T.0 from Eckbos legat 119145C.M.T. from the University of Bergen 154835
6 · The paper itself

Abstract

objectivesTo investigate whether infants exposed to antimicrobials in hospital during the first 3 months of life had an increased risk of ambulatory antimicrobial use during the following year compared with infants not exposed to antimicrobials during the first 3 months of life.

methodsNorwegian cohort study of infants less than 3 months consisting of one group exposed to antimicrobials recruited during hospitalization and one group not exposed to antimicrobials. Ten unexposed infants were matched with one exposed infant according to county of residence, birth year and month, and sex. The Norwegian Prescription Database was applied to register antimicrobial use from the month after discharge and 1 year onward. We defined comorbidity based on antimicrobials prescribed as reimbursable prescriptions due to underlying diseases.

resultsOf 95 infants exposed to antimicrobials during the first 3 months of life, 23% had recurrent use compared with 14% use in 950 unexposed infants [relative risk (RR) = 1.7 (95% CI = 1.1-2.5) and comorbidity-adjusted RR = 1.4 (95% CI = 0.9-2.2)]. The recurrence use rate in exposed term infants (≥37 weeks, n = 70) was 27% compared with 12% in their unexposed matches [RR 2.3 = (95% CI = 1.4-3.7) and comorbidity-adjusted RR = 1.9 (95% CI = 1.2-3.2). Of 25 exposed preterm infants, 3 (12%) had recurrent use. The total antimicrobial prescription rate was 674/1000 in the exposed group and 244/1000 in the unexposed group [incidence rate ratio = 2.8 (95% CI = 1.6-4.9)].

conclusionsInfants exposed to antimicrobials during the first 3 months of life had an increased risk of recurrent use during the following year. This increased risk also appeared in term infants without infection-related comorbidity.

Indexed as

Anti-Infective AgentsInfant, PrematureAnti-Bacterial AgentsCohort StudiesHospitalizationHumansInfantInfant, NewbornPatient DischargeAnti-Bacterial AgentsAnti-Infective Agents

Identifiers

PMID35137117
PMCPMC9047674
OpenAlexW4207035142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.