Evidence map›Paper›PMID 35137116›Full record

ReviewJournal of animal science2022

Function of m6A and its regulation of domesticated animals' complex traits.

Siyuan Mi, Yuanjun Shi, Gerile Dari, Ying Yu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of animal science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Comprehensive Analysis Revealed the Potential Roles of NInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Siyuan MiKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yuanjun ShiKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Gerile DariKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Ying YuKey Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
China Agricultural University · CN

Funding

Beijing Dairy Industry Innovation Team BAIC06China Agriculture Research System of MOF and MARA, Beijing Natural Science Foundation 6182021Major special projects of Ministry of Science and Technology during the Fourteen Five-year Plan Period 2021YFD1200900NSFC-PSF Joint Project 31961143009Program for Changjiang Scholar and Innovation Research Team in University IRT-15R62
6 · The paper itself

Abstract

N6-methyladenosine (m6A) is the most functionally important epigenetic modification in RNA. The m6A modification widely exists in mRNA and noncoding RNA, influences the mRNA processing, and regulates the secondary structure and maturation of noncoding RNA. Studies showed the important regulatory roles of m6A modification in animal's complex traits, such as development, immunity, and reproduction-related traits. As an important intermediate stage from animal genome to phenotype, the function of m6A in the complex trait formation of domestic animals cannot be neglected. This review discusses recent research advances on m6A modification in well-studied organisms, such as human and model organisms, and introduces m6A detection technologies, small-molecule inhibitors of m6A-related enzymes, interaction between m6A and other biological progresses, and the regulation mechanisms of m6A in domesticated animals' complex traits.

Indexed as

Animals, DomesticMultifactorial InheritanceAdenosineAnimalsRNA, MessengerRNA Processing, Post-TranscriptionalAdenosineRNA, Messengercomplex traitsdomesticated animalsinteractionm6A detection technologiesN6-methyladenosinesmall-molecule inhibitors

Identifiers

PMID35137116
PMCPMC8942107
OpenAlexW4211222105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.