Evidence map›Paper›PMID 35136971›Full record

ReviewBiology of reproduction2022

The future of assessing bull fertility: Can the 'omics fields identify usable biomarkers?†.

Erin K Klein, Aleona Swegen, Allan J Gunn, Cyril P Stephen, Robert John Aitken, Zamira Gibb

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology of reproduction, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  14. Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023
    Review
  15. Sperm Quality and Fertility of Livestock Animals.Animals : an open access journal from MDPI · 2023
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Erin K KleinPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
Aleona SwegenPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
Allan J GunnSchool of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
Cyril P StephenSchool of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
Robert John AitkenPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
Zamira GibbPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.
University of Newcastle Australia · AUCharles Sturt University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breeding soundness examinations for bulls rely heavily on the subjective, visual assessment of sperm motility and morphology. Although these criteria have the potential to identify infertile males, they cannot be used to guarantee fertility or provide information about varying degrees of bull fertility. Male factor fertility is complex, and the success of the male gamete is not necessarily realized until well after the spermatozoon enters the oocyte. This paper reviews our existing knowledge of the bull's contribution from a standpoint of the sperm's cargo and the impact that this can have on fertilization and the development of the embryo. There has been a plethora of recent research characterizing the many molecular attributes that can affect the functional competence of a spermatozoon. A better understanding of the molecular factors influencing fertilization and embryo development in cattle will lead to the identification of biomarkers for the selection of bulls of superior fertility, which will have major implications for livestock production. To see this improvement in reproductive performance, we believe incorporation of modern technology into breeding soundness examinations will be necessary-although many of the discussed technologies are not ready for large-scale field application. Each of the 'omics fields discussed in this review have shown promise for the identification of biomarkers of fertility, with certain families of biomarkers appearing to be better suited to different evaluations throughout a bull's lifetime. Further research is needed for the proposed biomarkers to be of diagnostic or predictive value.

Indexed as

Infertility, MaleSperm MotilityAnimalsBiomarkersCattleFertilityHumansMaleSpermatozoaBiomarkersbiomarkerbull fertilityfertility markerseminal plasmasperm

Identifiers

PMID35136971
PMCPMC9113469
OpenAlexW4210939243

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.