Evidence map›Paper›PMID 35136932›Full record

ArticleThe British journal of surgery2022

Effect of bariatric surgery on cancer risk: results from an emulated target trial using population-based data.

Andrea Lazzati, Salomé Epaud, Matthieu Ortala, Sandrine Katsahian, Emilie Lanoy

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In one paragraph

Article in The British journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 8 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 8 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  16. Target Trial Emulation for Evaluating Health Policy.Annals of internal medicine · 2024
    Article
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  19. Virus-like Particles for TEM Regulation and Antitumor Therapy.Journal of functional biomaterials · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrea LazzatiDepartment of General Surgery, Centre Hospitalier Intercommunal de Créteil, Créteil, France.ORCID 0000-0002-3572-3132
Salomé EpaudKaduceo SAS, Toulouse, France.
Matthieu OrtalaKaduceo SAS, Toulouse, France.
Sandrine KatsahianAssistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d'Épidémiologie et de Recherche Clinique, INSERM, Centre d'Investigation Clinique 1418, Module Épidémiologie Clinique, HEGP, Paris, France.
Emilie LanoyINSERM, IPLESP, équipe CLEPVIR.
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of weight loss induced by bariatric surgery on cancer occurrence is controversial. To study the causal effect of bariatric surgery on cancer risk from an observational database, a target-trial emulation technique was used to mimic an RCT.

methodsData on patients admitted between 2010 and 2019 with a diagnosis of obesity were extracted from a national hospital discharge database. Criteria for inclusion included eligibility criteria for bariatric surgery and the absence of cancer in the 2 years following inclusion. The intervention arms were bariatric surgery versus no surgery. Outcomes were the occurrence of any cancer and obesity-related cancer; cancers not related to obesity were used as negative controls.

resultsA total of 1 140 347 patients eligible for bariatric surgery were included in the study. Some 288 604 patients (25.3 per cent) underwent bariatric surgery. A total of 48 411 cancers were identified, including 4483 in surgical patients and 43 928 among patients who did not receive bariatric surgery. Bariatric surgery was associated with a decrease in the risk of obesity-related cancer (hazard ratio (HR) 0.89, 95 per cent c.i. 0.83 to 0.95), whereas no significant effect of surgery was identified with regard to cancers not related to obesity (HR 0.96, 0.91 to 1.01).

conclusionWhen emulating a target trial from observational data, a reduction of 11 per cent in obesity-related cancer was found after bariatric surgery.

Indexed as

Bariatric SurgeryNeoplasmsObesity, MorbidHumansObesityProportional Hazards ModelsWeight Loss

Identifiers

PMID35136932
OpenAlexW4205524466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.