Evidence map›Paper›PMID 35136904›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2022

Neuropsychological Performance in Autoimmune Limbic Encephalitis: Evidence from an Immunotherapy-Naïve Cohort.

Christoph Mueller, Lisa Langenbruch, Johanna M H Rau, Tobias Brix, Christine Strippel, Andre Dik, Kristin S Golombeck, Constanze Mönig, Andreas Johnen, Saskia Räuber and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Language impairments in seropositive and seronegative autoimmune encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Christoph MuellerDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.ORCID 0000-0003-1844-8009
Lisa LangenbruchDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Johanna M H RauDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Tobias BrixInstitute of Medical Informatics, Westfälische Wilhelms-University of Münster, Münster, Germany.
Christine StrippelDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Andre DikDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Kristin S GolombeckDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Constanze MönigDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Andreas JohnenDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Saskia RäuberDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Heinz WiendlDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Sven G MeuthDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Jens BölteInstitute of Psychology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Stjepana KovacDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.
Nico MelzerDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-University of Münster, Münster, Germany.ORCID 0000-0002-2420-701X
University of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAutoimmune limbic encephalitis (ALE) is characterized by memory impairment, psychiatric symptoms, and epileptic seizures. Though, the neuropsychological profile of ALE is not yet well defined. However, there is some evidence that neuropsychological impairments might exceed those related to the limbic system and that different autoantibodies (AABs) are associated with distinguishable pattern of neuropsychological impairments. We provide a comprehensive presentation of neuropsychological performance of ALE in an immune therapy-naïve sample.

methodsWe retrospectively analyzed 69 immunotherapy-naïve ALE-patients (26 seropositive-[8 LGI1-, 4 CASPR2-, 2 GABAB-R-, 3 Hu-, 4 GAD65-, 2 Ma2-, 2 unknown antigen, and 1 Yo-AABs] and 43 seronegative patients, mean age 56.0 years [21.9-78.2], mean disease duration 88 weeks [0-572]). Neuropsychological evaluations comprised of the domains memory, attention, praxis, executive functions, language, social cognition, and psychological symptoms. We compared these functions between seronegative -, seropositive patients with AABs against intracellular neural antigens and seropositive patients with AABs against surface membrane neural antigens.

resultsNo effect of AAB group on neuropsychological performance could be detected. Overall, ALE predominantly presents with deficits in long-term memory and memory recognition, autobiographical-episodic memory loss, impairment of emotion recognition, and depressed mood. Furthermore, deficits in praxis of pantomimes and imitations, visuo-construction, and flexibility may occur.

conclusionALE shows a wide spectrum of neuropsychological impairments, which might exceed the limbic system, with no evidence of differences between AAB groups. Neuropsychological assessment for diagnosing ALE should include long-term memory, memory recognition, autobiographical-episodic memory, emotion recognition, and a detailed investigation of depression.

Indexed as

AutoantibodiesMagnetic Resonance ImagingAutoimmune DiseasesHumansImmunotherapyLimbic EncephalitisMiddle AgedNeuropsychological TestsRetrospective StudiesAutoantibodiesAutoimmune limbic encephalitisCognitionEmotion recognitionMemoryNeuropsychological profilePraxis

Identifiers

PMID35136904
PMCPMC9113452
OpenAlexW4206462590

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.