Evidence map›Paper›PMID 35136823›Full record

ArticleERJ open research2022

Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge.

Akhilesh Jha, Fangyue Chen, Sam Mann, Ravi Shah, Randa Abu-Youssef, Holly Pavey, Helen Lin-Jia-Qi, Josh Cara, Daniel Cunningham, Kate Fitzpatrick and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 3 institutions in 1 country.

Akhilesh JhaDept of Medicine, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-8413-7738
Fangyue ChenDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sam MannSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Ravi ShahDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0002-3212-7706
Randa Abu-YoussefDept of Medicine, University of Cambridge, Cambridge, UK.
Holly PaveyDept of Medicine, University of Cambridge, Cambridge, UK.
Helen Lin-Jia-QiSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0001-8491-558X
Josh CaraSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Daniel CunninghamDept of Anaesthesia and Critical Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Kate FitzpatrickSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Celine GohSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Renee MaSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Souradip MookerjeeSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-4904-1324
Vaitehi NageshwaranDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Timothy OldDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0003-2564-2555
Catherine OxleySchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Louise JordonDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0002-0066-4750
Mayurun SelvanDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Anna WoodSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-2678-6369
Andrew YingSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Chen ZhangSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Dariusz WozniakRespiratory Support and Sleep Centre, Royal Papworth Hospital, Cambridge, UK.
Iain GoodhartDept of Anaesthesia and Critical Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Frances EarlyDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Marie FiskDept of Medicine, University of Cambridge, Cambridge, UK.
Jonathan FuldDept of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBPapworth Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProne positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence in awake non-ventilated patients, with most studies being retrospective, lacking control populations and information on subjective tolerability.

methodsWe conducted a prospective, single-centre study of prone positioning in awake non-ventilated patients with COVID-19 and non-COVID-19 pneumonia. The primary outcome was change in peripheral oxygenation in prone

results238 hospitalised patients with pneumonia were screened; 55 were eligible with 25 COVID-19 patients and three non-COVID-19 patients agreeing to undergo proning - the latter insufficient for further analysis. 10 healthy control volunteers underwent hypoxic challenge. Patients with COVID-19 had a median age of 64 years (interquartile range 53-75). Proning led to an increase in oxygen saturation measured by pulse oximetry (

conclusionIdentification of suitable patients with COVID-19 requiring oxygen supplementation from general ward environments for awake proning is challenging. Prone positioning leads to a small increase in

Identifiers

PMID35136823
PMCPMC8591389
OpenAlexW3211777501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.