Evidence map›Paper›PMID 35136569›Full record

ArticleF1000Research2021

A deep learning segmentation strategy that minimizes the amount of manually annotated images.

Thierry Pécot, Alexander Alekseyenko, Kristin Wallace

Abstract read
In one paragraph

Article in F1000Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Chikungunya virus replicates in the human testisEmerging microbes & infections · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thierry PécotDepartment of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29407, USA.ORCID 0000-0003-0772-9753
Alexander AlekseyenkoDepartments of Public Health Sciences and Oral Health Sciences, Biomedical Informatics Center, Medical University of South Carolina, Charleston, SC, 29407, USA.ORCID 0000-0002-5748-2085
Kristin WallaceDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29407, USA.

Funding

The immune contexture of colorectal adenomas and serrated polypsR01CA226086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WALLACE, KRISTIN · 2019 to 2023
$3.1M
Race, pathomolecular signature and colorectal cancer survivalK07CA151864 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WALLACE, KRISTIN · 2011 to 2015
$649k
NCI NIH HHS K07 CA151864NCI NIH HHS R01 CA226086
6 · The paper itself

Abstract

Deep learning has revolutionized the automatic processing of images. While deep convolutional neural networks have demonstrated astonishing segmentation results for many biological objects acquired with microscopy, this technology's good performance relies on large training datasets. In this paper, we present a strategy to minimize the amount of time spent in manually annotating images for segmentation. It involves using an efficient and open source annotation tool, the artificial increase of the training dataset with data augmentation, the creation of an artificial dataset with a conditional generative adversarial network and the combination of semantic and instance segmentations. We evaluate the impact of each of these approaches for the segmentation of nuclei in 2D widefield images of human precancerous polyp biopsies in order to define an optimal strategy.

Indexed as

Deep LearningCell NucleusHumansImage Processing, Computer-AssistedNeural Networks, ComputerSemanticsconditional GANsDeep learningimage annotationnuclei segmentationsemantic and instance segmentations

Identifiers

PMID35136569
PMCPMC8787559

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.