ArticleMolecular psychiatry2022
Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium.
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Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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38citing papers in PubMed, 1 pooled it
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- The role of cue transparency in task switching: an SDM-PSI meta-analysis in healthy adults.Brain imaging and behavior · 2026Pooled it
- Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism.General psychiatry · 2026Article
- Reduced Hand Specialization and Idiosyncratic Visuomotor Strategies in Autism During Naturalistic Object Manipulation.Autism research : official journal of the International Society for Autism Research · 2026Article
- Paw Preference in Rats Across Tests, Strains, Sex, and Age: A PRISMA-Compliant Systematic Review and Meta-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Morphometric Latent Factors in Autism and Their Association with Receptor Profiles and Behavior.bioRxiv : the preprint server for biology · 2025Article
- Cerebral blood flow changes and their genetic mechanisms in autism spectrum disorder: a combined neuroimaging and transcriptome study.European archives of psychiatry and clinical neuroscience · 2025Article
- Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders.Brain : a journal of neurology · 2025Review
- Charting structural brain asymmetry across the human lifespan.bioRxiv : the preprint server for biology · 2025Article
- Rightward brain structural asymmetry in young children with autism.Molecular psychiatry · 2025Article
- Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.CNS neuroscience & therapeutics · 2025Article
- Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence.Nature communications · 2025Article
- Multimodal Morphometric Similarity Network Analysis of Autism Spectrum Disorder.Brain sciences · 2025Article
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- The universe is asymmetric, the mouse brain too.Molecular psychiatry · 2025Article
- EEG Abnormalities and Phenotypic Correlates in Preschoolers with Autism Spectrum Disorder: A Single-Center Study.Journal of clinical medicine · 2025Article
- Microstructural asymmetry in the human cortex.Nature communications · 2024Article
- Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population.Molecular autism · 2024Article
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Authors and funding
58 authors at 20 institutions in 13 countries.
Zhiqiang ShaDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. zhiqiang.sha@mpi.nl.ORCID http://orcid.org/0000-0001-6604-6202
Daan van RooijDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Evdokia AnagnostouBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Celso ArangoChild and Adolescent Psychiatry Department, Institute of Psychiatry and Mental Health, Gregorio Maran General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Guillaume AuziasInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Universit, CNRS, Marseille, France.
Marlene BehrmannDepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Boris BernhardtMcConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9256-6041
Sven BolteCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4579-4970
Geraldo F BusattoLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Sara CalderoniIRCCS Stella Maris Foundation, Pisa, Italy.
Rosa CalvoDepartment of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9572-4228
Eileen DalyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience King's College London, London, UK.ORCID http://orcid.org/0000-0003-3625-3467
Christine DeruelleInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Universit, CNRS, Marseille, France.
Meiyu DuanBioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin, 130012, China.
Fabio Luis Souza DuranLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-7603-6152
Sarah DurstonBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Christine EckerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
Stefan EhrlichDepartment of Child and Adolescent Psychiatry & Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
Damien FairInstitute of Child Development, Department of Pediatrics, Masonic Institute of the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Jennifer FedorDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jacqueline FitzgeraldDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
Dorothea L FlorisDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4375-6572
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-9676-4782
Louise GallagherDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.ORCID http://orcid.org/0000-0001-9462-2836
David C GlahnDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115-5724, USA.
Shlomi HaarDepartment of Brain Sciences, Imperial College London, London, UK.
Liesbeth HoekstraDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Maria JalbrzikowskiDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Joost JanssenChild and Adolescent Psychiatry Department, Institute of Psychiatry and Mental Health, Gregorio Maran General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Joseph A KingDepartment of Child and Adolescent Psychiatry & Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology Hospital Clinic, Psychiatry Unit, Department of Medicine, 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jane McGrathDepartment of Psychiatry, School of Medicine, Trinity College, Dublin, Ireland.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Filippo MuratoriIRCCS Stella Maris Foundation, Pisa, Italy.
Declan G M MurphyThe Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6664-7451
Janina NeufeldCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7743-526X
Kirsten O'HearnDepartment of Physiology and Pharmacology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Bob OranjeBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Mara ParelladaChild and Adolescent Psychiatry Department, Institute of Psychiatry and Mental Health, Gregorio Maran General University Hospital, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Jose C ParienteMagnetic Resonance Image Core Facility, IDIBAPS (Institut d'Investigacions Biomdiques August Pi i Sunyer), Barcelona, Spain.ORCID http://orcid.org/0000-0002-7358-7602
Merel C PostemaDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Karl Lundin RemneliusCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Alessandra ReticoNational Institute for Nuclear Physics, Pisa Division, Largo B. Pontecorvo 3, Pisa, Italy.ORCID http://orcid.org/0000-0001-5135-4472
Pedro Gomes Penteado RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Katya RubiaInstitute of Psychiatry, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1410-7701
Devon ShookBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Kristiina TammimiesAstrid Lindgren Children's Hospital, Karolinska University Hospital, Region, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8324-4697
Margot J TaylorDiagnostic Imaging, The Hospital for Sick Children, and Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Michela TosettiIRCCS Stella Maris Foundation, Pisa, Italy.
Gregory L WallaceDepartment of Speech, Language, and Hearing Sciences, The George Washington University, Washington, DC, USA.
Fengfeng ZhouBioKnow Health Informatics Lab, College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin, 130012, China.ORCID http://orcid.org/0000-0002-8108-6007
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Simon E FisherDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Clyde FrancksDepartment of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. clyde.francks@mpi.nl.ORCID http://orcid.org/0000-0002-9098-890X
Radboud University Nijmegen · NLCentro de Investigación Biomédica en Red de Salud Mental · ESHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRKing's College London · GBTrinity College Dublin · IEUniversity Medical Center Utrecht · NLUniversity of Pittsburgh · USCentre National de la Recherche Scientifique · FRGoethe University Frankfurt · DEJilin University · CNKarolinska Institutet · SEMax Planck Institute for Psycholinguistics · NLTechnische Universität Dresden · DEUniversity of Pisa · ITUniversity of Southern California · USAtrium Health Wake Forest Baptist · USBoston Children's Hospital · USCarnegie Mellon University · USConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESCurtin University · AU
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0MTrauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MNeurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD SymptomsR01MH129832 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A, SCHMAAL, LIANNE · 2022 to 2025
$2.3MA global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5MNeurodevelopmental variation of intrinsic functional connectivity and its relationship to psychosis risk and gene expression - SupplementK01MH112774 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALBRZIKOWSKI, MARIA · 2017 to 2022
$884kNIA NIH HHS R01 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS P50 HD105351NIMH NIH HHS K01 MH112774NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH121246NIMH NIH HHS R01 MH129832
Abstract
Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of structural network effects have not previously been characterized. Inter-regional morphological covariance analysis can capture network connectivity between different cortical areas at the macroscale level. Here, we used cortical thickness data from 1455 individuals with ASD and 1560 controls, across 43 independent datasets of the ENIGMA consortium's ASD Working Group, to assess hemispheric asymmetries of intra-individual structural covariance networks, using graph theory-based topological metrics. Compared with typical features of small-world architecture in controls, the ASD sample showed significantly altered average asymmetry of networks involving the fusiform, rostral middle frontal, and medial orbitofrontal cortex, involving higher randomization of the corresponding right-hemispheric networks in ASD. A network involving the superior frontal cortex showed decreased right-hemisphere randomization. Based on comparisons with meta-analyzed functional neuroimaging data, the altered connectivity asymmetry particularly affected networks that subserve executive functions, language-related and sensorimotor processes. These findings provide a network-level characterization of altered left-right brain asymmetry in ASD, based on a large combined sample. Altered asymmetrical brain development in ASD may be partly propagated among spatially distant regions through structural connectivity.
Indexed as
Autism Spectrum DisorderBrainBrain MappingCerebral CortexHumansMagnetic Resonance ImagingNeural Pathways
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