Evidence map›Paper›PMID 35136200›Full record

ArticlePediatric research2022

Severity estimation of very-long-chain acyl-CoA dehydrogenase deficiency via

Keiichi Sugihara, Miori Yuasa, Yuko Isozaki, Ikue Hata, Yusei Ohshima, Takashi Hamazaki, Toshihiko Kakiuchi, Masato Arao, Noboru Igarashi, Yumiko Kotani and 4 more

Abstract read
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Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Keiichi SugiharaDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Miori YuasaDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yuko IsozakiDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Ikue HataDepartment of Pediatrics, Fukui Prefectural Hospital, Fukui, Japan.
Yusei OhshimaDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. yohshima@u-fukui.ac.jp.
Takashi HamazakiDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan.
Toshihiko KakiuchiDepartment of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan.
Masato AraoDepartment of Pediatrics, Saitama Medical University, Saitama, Japan.
Noboru IgarashiDepartment of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan.
Yumiko KotaniDepartment of Pediatrics, Tokushima University Hospital, Tokushima, Japan.
Tokiko FukudaDepartment of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan.
Reiko KagawaDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Go TajimaDivision of Neonatal Screening, Research Institute, National Center for Child Health and Development, Tokyo, Japan.
Yosuke ShigematsuDepartment of Pediatrics, Uji-Tokushukai Medical Center, Kyoto, Japan.
University of Fukui · JPFukui Prefectural Hospital · JPHamamatsu University School of Medicine · JPHiroshima University · JPNational Center For Child Health and Development · JPOsaka City University · JPSaga University · JPSaitama Medical University · JPTokushima University Hospital · JPToyama Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe clinical severity of very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is difficult to predict using conventional diagnostic methods.

methodsPeripheral blood mononuclear cells obtained from 14 VLCAD deficiency patients and 23 healthy adults were loaded with carbon-13-universally labeled (U-

resultsThere was a significant decrease in the

conclusionsOur data indicated that this method could be used to predict the clinical severity of VLCAD deficiency, and identify patients at a risk of severe disease. IMPACT: We established a novel method to predict the severity of VLCAD deficiency by performing a loading test with carbon-13-labeled fatty acids on peripheral blood mononuclear cells. The U-

Indexed as

CarnitineLeukocytes, MononuclearAcyl-CoA Dehydrogenase, Long-ChainAdultCarbon IsotopesCongenital Bone Marrow Failure SyndromesFatty AcidsHumansLipid Metabolism, Inborn ErrorsMitochondrial DiseasesMuscular DiseasesOleic AcidsStearic AcidsacylcarnitineAcyl-CoA Dehydrogenase, Long-ChainCarbon-13Carbon IsotopesCarnitineFatty AcidsOleic AcidsStearic Acids

Identifiers

PMID35136200
OpenAlexW4210894411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.