Evidence map›Paper›PMID 35136180›Full record

ArticleCommunications biology2022

Topological and enzymatic analysis of human Alg2 mannosyltransferase reveals its role in lipid-linked oligosaccharide biosynthetic pathway.

Meng-Hai Xiang, Xin-Xin Xu, Chun-Di Wang, Shuai Chen, Si Xu, Xiang-Yang Xu, Neta Dean, Ning Wang, Xiao-Dong Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Improving recombinant protein secretion inMetabolic engineering communications · 2025
    Article
  2. Cell-freeFrontiers in molecular biosciences · 2023
    Article
  3. AnFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Meng-Hai Xiang *Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.
Xin-Xin Xu *Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.
Chun-Di WangKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.
Shuai ChenKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.
Si XuKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China.
Xiang-Yang XuZaozhuang Jienuo enzyme co., Ltd, Zaozhuang, China.
Neta DeanDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.
Ning WangKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China. wangning@jiangnan.edu.cn.ORCID 0000-0001-5287-5755
Xiao-Dong GaoKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China. xdgao@jiangnan.edu.cn.ORCID 0000-0002-8575-5095
Jiangnan University · CNStony Brook University · US

Funding

Jiangsu Planned Projects for Postdoctoral Research Funds 2020Z167National Natural Science Foundation of China (National Science Foundation of China) 21778023; 21807048; 31971216; 22077053
6 · The paper itself

Abstract

N-glycosylation starts with the biosynthesis of lipid-linked oligosaccharide (LLO) on the endoplasmic reticulum (ER). Alg2 mannosyltransferase adds both the α1,3- and α1,6-mannose (Man) onto ManGlcNAc

Indexed as

MannosyltransferasesSaccharomyces cerevisiae ProteinsBiosynthetic PathwaysDolicholsHumansLipopolysaccharidesSaccharomyces cerevisiaeALG2 protein, S cerevisiaeDolicholslipid-linked oligosaccharidesLipopolysaccharidesMannosyltransferasesSaccharomyces cerevisiae Proteins

Identifiers

PMID35136180
PMCPMC8827073
OpenAlexW4210832190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.