ArticleScientific reports2022
The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 8 citations in OpenAlex.
- Robotic versus laparoscopic surgery for right-sided colon cancer: is it better for central lymph nodes harvesting in right colectomy with complete mesocolic excision?Surgical endoscopy · 2026Article
- Review
- Real-time indocyanine green fluorescence imaging enhances the precision of lymph node dissection in laparoscopic colon cancer surgery: a propensity score-matched cohort study.Surgical endoscopy · 2026Article
- Diagnostic and prognostic value of serum markers CEA, CA50, CA19-9, CA72-4, and CYFRA21-1 in colon cancer.Journal of medical biochemistry · 2026Article
- Thin Membranous Connective Tissue Encasing the Superior Mesenteric Vessels as an Objective Landmark for Robotic D3 Lymphadenectomy in Right-sided Colon Cancer: A Histological Study and Intraoperative Video Review.Journal of the anus, rectum and colon · 2026Article
- Poor prognosis in stage III colorectal cancer with apical lymph node metastasis: a single-center retrospective study.Updates in surgery · 2025Article
- A novel potential inflammation-nutrition biomarker for predicting lymph node metastasis in clinically node-negative colon cancer.Frontiers in oncology · 2023Article
- Comparing 5-Year Survival Rates Before and After Re-stratification of Stage I-III Right-Sided Colon Cancer Patients by Establishing the Presence/Absence of Occult Tumor Cells and Lymph Node Metastases in the Different Levels of Surgical Dissection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines.Frontiers in pharmacology · 2022Article
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10 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The effect of apical lymph node (APN) metastasis on the prognosis of colon cancer is unknown. The present study investigated the impact of APN metastasis on the prognosis of the patients with high-risk stage III colon cancer. This retrospective multi-institutional study included patients with pathological high-risk stage III colon cancer who underwent surgery between April 2009 and December 2014. Clinicopathological factors were examined by univariate and multivariate analyses to clarify independent risk factors for overall survival (OS) and relapse-free survival (RFS). A total of 185 patients were collected. The 5-year OS rates of patients with and without APN metastasis were 35.0% and 72.1%, respectively (p = 0.0014). The 5-year RFS rates of patients with and without APN metastasis was 16.2% and 57.2%, respectively (p = 0.0002). The rate of distant metastasis in patients with APN metastasis was significantly higher than that in patients without APN metastasis (68.8% vs. 36.7%, p = 0.012). The univariate analysis revealed that the differentiation, lymph node ratio, and APN metastasis were significantly associated with 5-year OS, and the preoperative CEA and CA19-9 levels and APN metastasis were significantly associated with 5-year RFS. The multivariate analysis showed that APN metastasis was an independent risk factor for 5-year OS and RFS. APN metastasis may be independently associated with the prognosis of patients with high-risk Stage III colon cancer.
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